亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
狠狠色噜噜狠狠狠狠色综合久 ,欧美黑人xxxxww
Rabbit Anti-SNAIL + SLUG/Gold Conjugated antibody (bs-11961R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11961R-Gold
英文名稱 Rabbit Anti-SNAIL + SLUG/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的鋅指轉(zhuǎn)錄因子Slug+SNAIL抗體
別    名 SNAIL+SLUG; dJ710H13.1; Protein sna; Protein snail homolog; SLUGH2; SNA; Sna protein; SNAH; SNAI1; Snail homolog 1 (Drosophila); Zinc finger protein SNAI1; SNAI1_HUMAN; Protein snail homolog 1; dJ710H13.1; SNAIL; SNAIL1; Protein sna; Neural crest transcription factor Slug; Protein snail homolog 2; Slug (chicken homolog) zinc finger protein; Slug homolog zinc finger protein; Slug zinc finger protein; SLUGH 1; SLUGH; SLUGH1; SNAI 2; SNAI2; SNAI-2; SNAI2_HUMAN; Snail 2; Snail homolog 2; Snail2; Snail-2; WS 2D; WS2D; Zinc finger protein SLUG; Zinc finger protein SNAI2.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, Danio rerio)
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 30kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SNAIL + SLUG (211-264aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
SNAIL: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008].
SLUG: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008].

Function:
Involved in the epithelial to mesenchymal transition (EMT) and formation and maintenance of embryonic mesoderm. Binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription.

Subunit:
Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif. Interacts (via SNAG domain) with WTIP (via LIM domains). Interacts (via SNAG domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains). Interacts with LOXL2 and LOXL3.

Subcellular Location:
Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.

Tissue Specificity:
Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.

Post-translational modifications:
Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination.
Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation.
O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and stabilizes the protein.

Similarity:
Belongs to the snail C2H2-type zinc-finger protein family.
Contains 4 C2H2-type zinc fingers.

Database links:

Entrez Gene: 6591 Human

Entrez Gene: 6615 Human

Entrez Gene: 20583 Mouse

Entrez Gene: 20613 Mouse

Omim: 604238 Human

SwissProt: O43623 Human

SwissProt: O95863 Human

SwissProt: P97469 Mouse

SwissProt: Q02085 Mouse

Unigene: 360174 Human

Unigene: 48029 Human

Unigene: 2093 Mouse

Unigene: 4272 Mouse




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
日韩精品成人av高清在线观看 | 天天澡天天添天天摸97影 | 中文字幕乱偷无码AV蜜桃 | 91欧洲在线视精品在亚洲 | 精品国产麻豆免费人成网站 | 蜜臀AV一区二区三区人妻在线 | 精品视频一区二区三区中文字幕 | 性成熟黑人双插美国1819 | 国产国产东北刺激毛片对白 | 日本在线精品视频观看 | 五月丁香综合缴情六月 | 国产刺激高潮免费不卡 | 在线观看黄网视频免费播放 | 在线观看日本一区 | 国产亚洲欧美成人久久片 | 男人的好看免费观看在线视频 | 蜜桃一区二区三区视频网址 | 国产精品欧美激情第一页 | 久青草国产97香蕉在线视频 | 欧美人妻AⅤ中文字幕 | 日韩特黄特色大片免费视频 | 9九色桋品熟女内射 | 《色诱女教师》在线观看 | 欧美日韩国产码综合一区在线 | 内射人妻无套中出无码 | 国产www在线观看 | 久久永久免费视频 | 波多野结衣三个女人蕾丝边 | 夜晚成人18禁区导航网站 | 国内精品人妻色欲无码久久久 | a级毛片免费全部播放无码 日韩久久久久精品一区二区三区 | 久久精品99久久久久久蜜芽TV | 中文字幕国产精品高潮呻吟久久av无码 | 一级a性色生活片久久无码火 | 大肉大捧一进一出的视频 | 米奇奇米777第四色 国产精品免费大片 | 内射人妻无码色AV无码 | 国产精品无码免费专区午夜 | 免费精品一区二区三区在线观看 | 亚洲日韩国产成在线发布一区二区三区 | 精品21国产成人综合网在线 |