亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
中文字幕人妻无码系列第三区,亚洲AV无码李区亚洲A
Rabbit Anti-SNAIL + SLUG/PE-Cy7 Conjugated antibody (bs-11961R-PE-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11961R-PE-Cy7
英文名稱 Rabbit Anti-SNAIL + SLUG/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的鋅指轉(zhuǎn)錄因子Slug+SNAIL抗體
別    名 SNAIL+SLUG; dJ710H13.1; Protein sna; Protein snail homolog; SLUGH2; SNA; Sna protein; SNAH; SNAI1; Snail homolog 1 (Drosophila); Zinc finger protein SNAI1; SNAI1_HUMAN; Protein snail homolog 1; dJ710H13.1; SNAIL; SNAIL1; Protein sna; Neural crest transcription factor Slug; Protein snail homolog 2; Slug (chicken homolog) zinc finger protein; Slug homolog zinc finger protein; Slug zinc finger protein; SLUGH 1; SLUGH; SLUGH1; SNAI 2; SNAI2; SNAI-2; SNAI2_HUMAN; Snail 2; Snail homolog 2; Snail2; Snail-2; WS 2D; WS2D; Zinc finger protein SLUG; Zinc finger protein SNAI2.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, Danio rerio)
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 30kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SNAIL + SLUG (211-264aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
SNAIL: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008].
SLUG: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008].

Function:
Involved in the epithelial to mesenchymal transition (EMT) and formation and maintenance of embryonic mesoderm. Binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription.

Subunit:
Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif. Interacts (via SNAG domain) with WTIP (via LIM domains). Interacts (via SNAG domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains). Interacts with LOXL2 and LOXL3.

Subcellular Location:
Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.

Tissue Specificity:
Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.

Post-translational modifications:
Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination.
Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation.
O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and stabilizes the protein.

Similarity:
Belongs to the snail C2H2-type zinc-finger protein family.
Contains 4 C2H2-type zinc fingers.

Database links:

Entrez Gene: 6591 Human

Entrez Gene: 6615 Human

Entrez Gene: 20583 Mouse

Entrez Gene: 20613 Mouse

Omim: 604238 Human

SwissProt: O43623 Human

SwissProt: O95863 Human

SwissProt: P97469 Mouse

SwissProt: Q02085 Mouse

Unigene: 360174 Human

Unigene: 48029 Human

Unigene: 2093 Mouse

Unigene: 4272 Mouse




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
久久婷综合五月天啪网 | 日韩免费视频一区 | 丰满少妇被猛男猛烈进入久久 | 青青草97国产精品免费观看 | 免费观看一级特黄欧美 | 欧美乱妇日本无乱码特黄大片 | 欧洲无人区卡一卡二卡三 | 蜜芽192.MON牢记永不失联 | 男女激情无遮挡免费视频 | 国产亚洲自拍一区 | 夫妻免费无码V看片 | 精品国产刺激国语对白 | 最近中文字幕MV免费高清动漫 | 黄色三级网站免费 | 又大又粗进出白浆直流视频在线 | 欧美精品黄网站在线播放 | 欧美综合自拍亚洲综合百度 | 第一天破了英语课代表的处 | 无码乱码精品少妇一级内射 | 色哦色哦哦色天天综合 | …久久精品99久久香蕉国产 | 中文国产成人AⅤ久久 | 免费黃色三級片在线观看18 | 91精品国产麻豆国产自产在线 | 国产AV午夜精品一区二区入口 | 自拍偷区亚洲综合第一页欧18 | 免费又黄又硬又爽大片 | 亚洲成a人片在线观看无码专区 | 18禁黄网站禁片免费观看久久 | 免费观看成人久久网免费观看 | 日产乱码一区二区三区在线 | 又大又粗进出白浆直流视频在线 | 亚洲AV成人无码一二三在线观看 | 小受bl灌满白浊夹多人4p | 久久经典免费视频 | 91精品国产91热久久p | 91精品视频网站 | 午夜欧美日韩国产福利91不卡一区二区三区 | 美女裸体动态图片 | 国产精品VA在线播放 | 日韩精品人妻AV一区二区三区 |