亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
97se色在在线视频,国产精品VA在线播放
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-SPG3A/Cy3 Conjugated antibody (bs-11759R-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-11759R-Cy3
英文名稱 Rabbit Anti-SPG3A/Cy3 Conjugated antibody
中文名稱 Cy3標記的G蛋白結(jié)合蛋白3抗體
別    名 Atlastin; AD FSP; atl1; ATLA1_HUMAN; Atlastin GTPase 1; Atlastin-1; Atlastin1; Brain specific GTP binding protein; Brain-specific GTP-binding protein; FSP1; GBP-3; GBP3; GTP-binding protein 3; Guanine nucleotide-binding protein 3; Guanylate binding protein 3; hGBP3; HSN1D; Spastic paraplegia 3 protein A; SPG 3A; SPG3; SPG3A.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  結(jié)合蛋白  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPG3A/Atlastin (201-300aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40%.

Function:
GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.

Subunit:
Homooligomer. Interacts (via N-terminal region) withMAP4K4 (via CNH regulatory domain). Interacts with REEP5, RTN3 andRTN4 (via the transmembrane region). Interacts with SPAST;interaction is direct. May interact with TMED2. Interacts withREEP1.

Subcellular Location:
Endoplasmic reticulum membrane. Golgi apparatus membrane. Cell projection > axon.

Tissue Specificity:
Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level).

DISEASE:
Defects in ATL1 are the cause of spastic paraplegia autosomal dominant type 3 (SPG3) [MIM:182600]; also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.

Similarity:
Belongs to the GBP family. Atlastin subfamily.

Database links:

Entrez Gene: 51062 Human

Entrez Gene: 73991 Mouse

Entrez Gene: 362750 Rat

Entrez Gene: 535424 Cow

Omim: 606439 Human

SwissProt: Q58D72 Cow

SwissProt: Q8WXF7 Human

SwissProt: Q8BH66 Mouse

SwissProt: Q6PST4 Rat

Unigene: 584905 Human

Unigene: 474462 Mouse

Unigene: 135117 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
精品少妇AV无码免费久久洗澡 | a毛片在线看免费观看 | 国产午夜精品喷水久久 | 国产精品视频第一区二区三区 | 日韩欧美一区二区三区久久婷婷 | 成人片在线观看地址KK4444 | 国产欧美日韩一区二区搜索 | 美女视频黄a视频全免费网站色窝 | 欧美亚洲清纯国产综合图区 | A国产一区二区免费入口 | 狂处让老二爽18p | 中文在线最新版天堂8 | 少妇内射兰兰久久 | 国产精品视频一区国模私拍 | 最近最新精品欧美日本韩亚洲中文国产 | 99国产精品久久久久99打野战 | 欧美又黄又粗又大AV毛 | 二级毛片在线观看 | 欧美三级在线免费观看 | 亚洲精品欧美精品中文字幕 | 日欧片内射AV影院频道 | 粗大的内捧猛烈进出视频网 | 免费的很污的很黄的网站 | 亚洲熟妇无码爱V在线观 | 免费国产成人高清在线网站东京 | 中文字幕色综合久久 | 91福利在线观看 | 人妻欧美精品AAAAAAAAA片 | 国产禁忌A级毛片中字内射 亚洲AV福利天堂一区二区三 | 成人午夜福利视频后入 | C日本学生妹视频色呦呦 | 中文字幕一区在线观看视频 | 中文字日产幕码三区的做法大全 | 亚洲乱码精品久久久久.. | 国产精品一区二区AV日韩在线 | 嗯好湿用力的啊c进来动态图 | 日韩精品久久久肉伦网站 | 二级毛片在线观看 | 亚洲欧美在线观看H片 | 精品久久久无码人妻中文字幕边打电话 | 亚洲无人区码一码二码三码四码 |