亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
美国乱码日产精品BD在线观看,日韩欧美一区二区三区在线视频
Rabbit Anti-UBE3A/BF488 Conjugated antibody (bs-11776R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-11776R-BF488
英文名稱 Rabbit Anti-UBE3A/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的人乳頭狀瘤病毒E6相關(guān)蛋白抗體
別    名 ANCR; Angelman syndrome; AS; CTCL tumor antigen se37 2; E6 AP; E6-AP; E6AP antibody E6AP ubiquitin protein ligase; E6AP ubiquitin protein ligase; E6AP ubiquitin-protein ligase; EPVE6AP; HPVE6A; Human papilloma virus E6 associated protein Angelman syndrome; Human papilloma virus E6 associated protein; Human papillomavirus E6-associated protein; NY REN 54 antigen; NY REN 54 antigen; Oncogenic protein associated protein E6 AP; Oncogenic protein associated protein E6AP; Oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY REN 54; Renal carcinoma antigen NY-REN-54; UBE 3A; Ube3a; UBE3A protein; UBE3A_HUMAN; Ubiquitin protein ligase E3A; Ubiquitin-protein ligase E3A.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  表觀遺傳學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 105kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human UBE3A/E6-AP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
E6-associating protein is a component of the ubiquitin-mediated proteolytic pathway, which selectively targets proteins for degradation by the 26S proteasome. Ubiquitin (Ub) is directly conjugated to protein substrates by the transfer of Ub from an E2 ubiquitin conjugating enzyme to the target protein. This conjugation is facilitated by the enzymatic activity of E3 ubiquitin ligase family members such as E6-AP. Several substrates of E6-AP have been identified and include the tumor suppressor protein p53 and the mammalian homolog of Rad23, HHR23A. Previous studies have indicated that E6-AP associates with the human papillomavirus E6 oncogene, which complexes with p53 and thereby potentiates E6-AP mediated ubiquitination of p53. Genetic mutations that impair E6-AP activity result in the accumulation of p53 in the cytoplasm, and, in many instances, these mutations are associated with the development of the rare neurodevelopmental disorder Angelman syndrome (AS), which is characterized by severe motor dysfunction and mental retardation.

Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE:
Defects in UBE3A are a cause of Angelman syndrome (AS) [MIM:105830]; also known as 'happy puppet syndrome'. AS is characterized by features of severe motor and intellectual retardation, microcephaly, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, hyperactivity, hypopigmentation, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, and an unusual facies characterized by macrostomia, a large mandible and open-mouthed expression, a great propensity for protruding the tongue ('tongue thrusting'), and an occipital groove.

Similarity:
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.

Database links:

Entrez Gene: 7337 Human

Entrez Gene: 22215 Mouse

Entrez Gene: 361585 Rat

Omim: 601623 Human

SwissProt: Q05086 Human

SwissProt: Q96GR7 Human

SwissProt: O08759 Mouse

Unigene: 598862 Human

Unigene: 9002 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产免费AV片在线播放唯爱网 | 娇妻在客厅被朋友玩得呻吟漫画 | SWAG台湾极品高潮内射 | 91在线国内精品自产拍 | 2019年国产高清情侣视频 | 可以在线观看的黄色网址 | 免费无码又爽又刺激网站直播 | 亚洲精品国产不卡在线观看 | 日韩十八禁在线1区2区3区不卡 | 精品性影院一区二区三区内射 | 蜜桃一区二区三区视频网址 | 91人妻精品一区二区三区蜜桃 | 夜夜添无码试看一区二区三区 | 牝教师4~秽された教坛~第6集 | 性妇WBBBB搡BBBB嗓1 | 在线无码一区二区三区不卡 | 精品少弄得99久久精品区别 | 日日摸日日踫夜夜爽无码 | 高清有码国产一区二区 | 国产裸体美女永久免费无遮挡 | 丰满少妇被猛烈进入无码蜜桃 | 国产 浪潮AV性色四虎 | 最近的2019中文字幕国语HD | 无码毛片内射白浆视频 | 国产二级一片内射视频插放 | 美女被强无套内射视频漫画 | 美女被抽插到哭内射视频免费 | 品产品久精国精产拍20 | 双飞风韵犹存两个熟妇 | 在线永久免费观看黄网站 | 我和闺蜜在公车被cao污文 | 国产精品宾馆精品酒店 | 中文字幕人妻少妇引诱隔壁 | 亚洲日韩在线观看 | 给我免费播放片在线中国 | 久久久久久久精品国产亚洲蜜臀 | 精品极品三大极久久久久 | 亚洲中文字幕婷婷在线 | 国产又粗又大又爽又免费视频 | 亚洲人成人无码.WWW石榴 | 久久久久久一级毛片免费野外 |