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Rabbit Anti-ZNF3/BF488 Conjugated antibody (bs-12216R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-12216R-BF488
英文名稱 Rabbit Anti-ZNF3/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的鋅指蛋白3抗體
別    名 A8 51; C2 H2 type zinc finger protein; FLJ20216; HF.12; HZF3.1; KOX25; PP838; Zfp113; Zinc finger protein 3 (A8 51); Zinc finger protein 3; Zinc finger protein HF.12; Zinc finger protein KOX25; ZNF3_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human ZNF3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
產(chǎn)品介紹 background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kruppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF3, also known as KOX25, is a zinc finger protein belonging to the Kruppel C(2)H(2)-type zinc finger protein family. It localizes to the nucleus and is involved in cell differentiation and proliferation. ZNF3 is a 446 amino acid long protein that contains eight C(2)H(2)-type zinc fingers and one KRAB domain. ZNF3 is located in a cluster of KOX zinc-finger genes found on chromosome 10.

Function:
A zinc finger is a protein domain that can bind to DNA. A zinc finger consists of two antiparallel ?sheets, and an alpha helix. The structure of each individual finger is highly conserved and consists of about 30 amino acid residues, constructed as a 哌alpha fold and held together by the zinc ion. The alpha helix occurs at the C terminal part of the finger, while the ?sheet occurs at the N terminal part.

Subcellular Location:
Nuclear

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 8 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Database links:

Entrez Gene: 7551 Human

Omim: 194510 Human

SwissProt: P17036 Human

Unigene: 435302 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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