亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
色欲日本人妻久久久久久综合,免费无码又爽又刺激网站直播 ,久久久久亚洲女同一区二区
Rabbit Anti-COP1/PE-Cy3 Conjugated antibody (bs-13925R-PE-Cy3)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-13925R-PE-Cy3
英文名稱(chēng) Rabbit Anti-COP1/PE-Cy3 Conjugated antibody
中文名稱(chēng) PE-Cy3標(biāo)記的E3泛素蛋白連接酶COP1抗體
別    名 Constitutive photomorphogenesis protein 1 homolog; COP; E3 ubiquitin-protein ligase RFWD2; hCOP1; RFWD2; RFWD2_HUMAN; RNF200; ring finger and WD repeat domain 2; RING finger and WD repeat domain protein 2; RING finger protein 200.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 信號(hào)轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  泛素  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human COP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
COP1 is an E3 ubiquitin ligase protein that mediates ubiquitination and degradation of target proteins such as c-Jun and p53. It is a component of the DCX DET1-COP1 ubiquitin ligase complex which consists of RBX1, DET1, DDB1, CUL4A and COP1. Localizing to the cytoplasm and to the nucleus, COP1 is primarily expressed in testis, placenta, heart and skeletal muscle. COP1 is a potent inhibitor of p53-dependent transcription and apoptosis but, when phosphorylated by Atm (ataxia telangiectasia mutated) in response to DNA damage, the COP1-p53 complex is disrupted and p53 is allowed to exert its pro-apoptotic properties. In ovarian and breast cancers, COP1 is overexpressed, suggesting a role for COP1 in tumorigenesis.

Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.

Subcellular Location:
Nucleus speckle. Cytoplasm. In the nucleus, it forms nuclear speckles.

Tissue Specificity:
Ubiquitously expressed at low level. Expressed at higher level in testis, placenta, skeletal muscle and heart.

Similarity:
Belongs to the COP1 family.
Contains 1 RING-type zinc finger.
Contains 7 WD repeats.

Database links:

Entrez Gene: 64326 Human

Entrez Gene: 26374 Mouse

Omim: 608067 Human

SwissProt: Q8NHY2 Human

SwissProt: Q9R1A8 Mouse

Unigene: 523744 Human

Unigene: 328135 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
人妻体内射精一区二区三四 | 欧美一区二区三区久久综 | 在线观看国产精品女主播 | 无码av中文字幕免费放 | 91免费永久在线地址 | 国产成人 亚洲 欧洲在线 | 影音先锋国产精品网站 | 亚洲爆乳无码精品AAA片蜜桃 | 亚洲国产成人精品刺激内射白浆 | 日本成本人片高清久久免费 | 久久国产乱子精品免费女 | 人妻少妇精品视频一区二区三区 | 全黄裸片一29分钟免费真人版 | 久久狠狠色噜噜狠狠狠狠97 | 国产欧美一区二区精品性色超碰 | 欧美日韩无线码免费播放器 | 国产A级毛片久久久久久精品 | 麻豆一二三区AV传媒 | 国偷自产AV一区二区三区健身房 | 国产午夜人做人免费视频APP | 久久国产精品99精国产 | 精品一级毛片免费视频 | 国产深夜福利在线观看网站 | 亚洲精品一本之道高清乱码 | 亚洲精品白浆高清久久久久久 | 免费可以看黄的视频s色 | 99久久免费国产精品特黄 | 国产内射在线激情一区 | 伊人婷婷涩六月丁香七月 | 在线欧美精品一区二区三区 | 国产精品亚洲AV毛片一区二区三区 | 91精品国产麻豆国产自产在线 | 欧美人妻AⅤ中文字幕 | 99久久精品免费看国产一区二区三区 | 欧美人与黑人牲交全过程视 | 秋葵视频ios无限制解码免费版下载 | 男人的天堂精品国产一区 | 内射少妇三洞齐开 | 丰满少妇被猛烈高清播放 | 久久久久久久久66精品片 | 国产精品禁18久久久夂久 |