亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
日韩熟妇啪啪无码视频,91精品手机国产在线播放,av网站免费线看
Rabbit Anti-phospho-COP1 (Ser387)/FITC Conjugated antibody (bs-13976R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-13976R-FITC
英文名稱 Rabbit Anti-phospho-COP1 (Ser387)/FITC Conjugated antibody
中文名稱 FITC標(biāo)記的磷酸化E3泛素蛋白連接酶COP1抗體
別    名 COP1 (phospho S387); p-COP1 (phospho S387); Constitutive photomorphogenesis protein 1 homolog; COP; E3 ubiquitin-protein ligase RFWD2; hCOP1; RFWD2; RFWD2_HUMAN; RNF200; ring finger and WD repeat domain 2; RING finger and WD repeat domain protein 2; RING finger protein 200.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 信號(hào)轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human COP1 around the phosphorylation site of Ser387
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
COP1 is an E3 ubiquitin ligase protein that mediates ubiquitination and degradation of target proteins such as c-Jun and p53. It is a component of the DCX DET1-COP1 ubiquitin ligase complex which consists of RBX1, DET1, DDB1, CUL4A and COP1. Localizing to the cytoplasm and to the nucleus, COP1 is primarily expressed in testis, placenta, heart and skeletal muscle. COP1 is a potent inhibitor of p53-dependent transcription and apoptosis but, when phosphorylated by Atm (ataxia telangiectasia mutated) in response to DNA damage, the COP1-p53 complex is disrupted and p53 is allowed to exert its pro-apoptotic properties. In ovarian and breast cancers, COP1 is overexpressed, suggesting a role for COP1 in tumorigenesis.

Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.

Subcellular Location:
Nucleus speckle. Cytoplasm. In the nucleus, it forms nuclear speckles.

Tissue Specificity:
Ubiquitously expressed at low level. Expressed at higher level in testis, placenta, skeletal muscle and heart.

Similarity:
Belongs to the COP1 family.
Contains 1 RING-type zinc finger.
Contains 7 WD repeats.

Database links:

Entrez Gene: 64326 Human

Entrez Gene: 26374 Mouse

Omim: 608067 Human

SwissProt: Q8NHY2 Human

SwissProt: Q9R1A8 Mouse

Unigene: 523744 Human

Unigene: 328135 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
最近中文字幕mv免费高清在线视频 | 亚洲日韩在线男人视频网站 | 国产一级第一级毛片 | h嗯啊~玉足稚嫩奶娃脚乱女 | √天堂中文在线最新版 | 欧美日韩人妻精品一区在线 | gvg454真实性教育在线播放 | 国产一级高清A片免费播 | 亚洲精品高清AV在线播放 | 日本最新免费的一区二区 | 久久国产乱子精品免费女 | 日产精品美女久久久网站大全 | 免费在线看一级黄色网站 | 欧美成人精品欧美一级乱黄 | 91热成人精品国产免费 | 欧美午夜精品久久久久久浪潮 | 成人无码视频在线播放 | 久久AAAA片一区二区 | 中文字幕无码一区二区免费 | 日韩欧美中文字幕公布 | 欧美日韩精品国产一区在线 | 久色乳综合思思在线视频 | 成人午夜精品网站在线观看 | 日韩久久久久久无码精品 | 波多野结衣av一区二区全免费观看 | 亚洲啪AV永久无码精品放毛片 | 精品自拍视频五区六区在线观看 | 奇米综合四色77777久久 | 无套内射极品少妇CHINESE | 国产麻豆成人传媒免费观看 | 日本午夜精品一区二区三区电影 | 国产在线一区二区三区四区 | 香蕉有码在线视频发布 | 精品日产1区2卡三卡麻豆 | 免费无码又爽又刺激高潮久久 | 依恋社区影院网在线观看 | 国产在线高清视频 | 婷婷伊人久久大香线蕉AV | 日本高清在线天码一区播放 | 国产又爽又黄又爽又刺激 | 一本大道中文日本香蕉 |