亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
yy6080影院色呦呦私人,国产在线精品福利大全
Rabbit Anti-phospho-COP1 (Ser387)/PE-Cy3 Conjugated antibody (bs-13976R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-13976R-PE-Cy3
英文名稱 Rabbit Anti-phospho-COP1 (Ser387)/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的磷酸化E3泛素蛋白連接酶COP1抗體
別    名 COP1 (phospho S387); p-COP1 (phospho S387); Constitutive photomorphogenesis protein 1 homolog; COP; E3 ubiquitin-protein ligase RFWD2; hCOP1; RFWD2; RFWD2_HUMAN; RNF200; ring finger and WD repeat domain 2; RING finger and WD repeat domain protein 2; RING finger protein 200.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 信號轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human COP1 around the phosphorylation site of Ser387
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
COP1 is an E3 ubiquitin ligase protein that mediates ubiquitination and degradation of target proteins such as c-Jun and p53. It is a component of the DCX DET1-COP1 ubiquitin ligase complex which consists of RBX1, DET1, DDB1, CUL4A and COP1. Localizing to the cytoplasm and to the nucleus, COP1 is primarily expressed in testis, placenta, heart and skeletal muscle. COP1 is a potent inhibitor of p53-dependent transcription and apoptosis but, when phosphorylated by Atm (ataxia telangiectasia mutated) in response to DNA damage, the COP1-p53 complex is disrupted and p53 is allowed to exert its pro-apoptotic properties. In ovarian and breast cancers, COP1 is overexpressed, suggesting a role for COP1 in tumorigenesis.

Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.

Subcellular Location:
Nucleus speckle. Cytoplasm. In the nucleus, it forms nuclear speckles.

Tissue Specificity:
Ubiquitously expressed at low level. Expressed at higher level in testis, placenta, skeletal muscle and heart.

Similarity:
Belongs to the COP1 family.
Contains 1 RING-type zinc finger.
Contains 7 WD repeats.

Database links:

Entrez Gene: 64326 Human

Entrez Gene: 26374 Mouse

Omim: 608067 Human

SwissProt: Q8NHY2 Human

SwissProt: Q9R1A8 Mouse

Unigene: 523744 Human

Unigene: 328135 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
天天躁日日躁狠狠躁AV麻豆 | 另类老太婆BBWBBW | 国产成人一区二区三中文 | 欧洲美女人**一级毛片 | 99精品久久久久久人妻精品 | 国产va免费精品高清在线 | 国产娱乐凹凸视觉盛宴在线视频 | 中国免费一级毛片 | 一级毛片人与动免费观看 | XXX2高清在线观看免费视频 | 视频一区在线免费观看 | 天天se天天gan综合网 | 特级毛片A级毛片免费观看网站 | 91露出自慰白浆一区二区 | 亚洲国产香蕉视频欧美 | 日韩美女在线视频一区不卡 | 欧美激情二区三区 | 欧美激情成a人在线观看 | 中文字幕AV在线一二三区 | 日韩欧美高清黄大片色成人精品香蕉在线看 | ANGELINA全集在线播放 | 欧美日韩无线码一区茄子视频 | 久久国产精品偷任你爽任你A | 国产香蕉九九久久精品免费 | 午夜亚洲国产理论片一二三四 | 久久亚洲国产成人综合久久精品 | 亚洲乱码国产乱码精华 | 国产欧美日韩高清在线不卡 | 1区2区3区高清视频 动漫爆乳无遮挡免费观看 精品人妻中文字幕在线 | 色综合久久综合网欧美综合网 | 黄网站色视频大全免费观看 | 美女网站在线观看视频18 | 一级a性色生活片久久无 | 日本黄H兄妹H动漫一区二区三区 | 永久免费看啪啪网址入口 | 欧美成人亚洲国产精品 | 美女内射毛片在线看3D | 特黄四级人牲片在线观看 | 男人的好看视频1在线观看 久久国产免费一区二区三区 | 一级毛片视频免费 | 欧美特黄三级成人 |