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Rabbit Anti-THEMIS/Gold Conjugated antibody (bs-12329R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-12329R-Gold
英文名稱 Rabbit Anti-THEMIS/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的選擇性胸腺細(xì)胞相關(guān)蛋白抗體
別    名 C6orf190; C6orf207; MGC163388; Protein THEMIS; THMS1_HUMAN; Thymocyte expressed molecule involved in selection; Thymocyte selection associated; Thymocyte selection pathway associated; Thymocyte-expressed molecule involved in selection; TSEPA.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 干細(xì)胞  淋巴細(xì)胞  t-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Pig, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human THEMIS
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Themis is a 641 amino acid nuclear and cytoplasmic protein that exists as three alternatively spliced isoforms. Themis belongs to the themis family and interacts with PLC γ1, Emt and GRB2. Acting through T-cell antigen receptor (TCR) signaling and through the regulation of calcium influx and phosphorylation of ERK 1, Themis plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Themis is phosphorylated on Tyr residues quickly after TCR stimulation. The gene that encodes Themis maps to human chromosome 6q22.33. With 170 million base pairs, chromosome 6 comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Function:
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.

Subcellular Location:
Cytoplasm. Nucleus.

Post-translational modifications:
Phosphorylated on Tyr residues quickly after TCR stimulation.

Similarity:
Belongs to the themis family.

Database links:

Entrez Gene: 387357 Human

Entrez Gene: 210757 Mouse

Omim: 613607 Human

SwissProt: Q8N1K5 Human

SwissProt: Q8BGW0 Mouse

Unigene: 661756 Human

Unigene: 123021 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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