亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
全免费A级毛片免费看无码播放,麻豆国产精品番甜甜七夕,亚洲专区无码天堂中文字幕
Rabbit Anti-phospho-Dematin (Ser403)/BF350 Conjugated antibody (bs-14266R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-14266R-BF350
英文名稱 Rabbit Anti-phospho-Dematin (Ser403)/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的磷酸化紅細(xì)胞膜帶4.9蛋白抗體
別    名 Dematin (phospho S403); P-Dematin (phospho S403); DEMA; DEMA_HUMAN; Dematin; DMT; EPB49; erythrocyte membrane protein band 4.9 (dematin); Erythrocyte membrane protein band 4.9.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  結(jié)合蛋白  細(xì)胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Dematin around the phosphorylation site of Ser403
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]

Function:
Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.

Subunit:
Monomeric (isoform 2); under reducing conditions. Self-associates. Exists under oxidizing condition as a trimer of two isoforms 2 and isoform 1 linked by disulfide bonds (Probable). Found in a complex with DMTN, F-actin and spectrin. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with F-actin, ITPKB, RASGRF2 and spectrin. Isoform 2 interacts with SLC2A1 (via C-terminus cytoplasmic region). Isoform 1 and isoform 2 interact (phosphorylated form) with plasmodium berghei 14-3-3 protein; the interaction occurs in a PKA-dependent manner.

Subcellular Location:
Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane. Membrane. Endomembrane system. Cell projection. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuol in malaria-infected erythrocytes at late stages of plasmodium berghei or falciparum development.

Tissue Specificity:
Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney.

Post-translational modifications:
Phosphorylated. Phosphorylation at Ser-403 by PKA causes the C-terminal headpiece domain to associate with the N-terminal core domain, and leads to the inhibition of its actin bundling activity.
The N-terminus is blocked.

Similarity:
Belongs to the villin/gelsolin family.
Contains 1 HP (headpiece) domain.

Database links:

Entrez Gene: 2039 Human

Entrez Gene: 13829 Mouse

Entrez Gene: 361069 Rat

Omim: 125305 Human

SwissProt: Q08495 Human

SwissProt: Q9WV69 Mouse

Unigene: 106124 Human

Unigene: 210863 Mouse

Unigene: 446654 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
内射豹纹少妇-V11AV | 亚洲精品欧美精品中文字幕 | 国产欧美日韩综合一区在线播放 | 色婷婷AV一区二区三区在线观看 | 综合精品欧美日韩在线观看 | 久久99人妻无码精品一区二区 | 久久久这里只有免费精品2018 | 苍井空毛片精品久久久 | 黄色网站免费在线观看 | 日韩精品区一区二区三VR | 天天躁夜夜躁狠狠是什么心态 | 永久免费A片在线观看无码 免费一级A片毛毛片在线播放99 | 日韩高清在线观看永久 | 亚洲AV无码专区一级婬片毛片 | 亚洲乱码精品久久久久.. | 欧美日韩免费在线 | 日韩一级精品久久久久 | 国产成人午夜精品免费视频 | 丰满妇女BBWBBWBBWBBW | 国产美女久久久久久久久久久 | 久久青青草原精品国产软件 | 色一情一乱一伦一区二区三区 | 插插射啊爱视频日A级 | 麻豆一二三区AV传媒 | 一区二区三区视频在线观看 | 老色皮永久免费网站 | 麻豆AV无码精品一区二区 | 无码AV大香线蕉伊人久久九色 | 加勒比AV一本大道香蕉大在线 | 国产特级毛片AAAAAAA高清 | 亚洲欧美激情精品一区二区 | 夜里十大禁用短视频软件 | 丰满爆乳肉感一区二区三区 | 久久一区二区三区精华液使用方法 | 国产中文在线观看 | 久久丁香婷深爱五月天网 | 精品成a人亚洲精品无码 | 国产精品久久久久久福利 | 最新国产精品精品视频 | 久久久av久av久片一区二区 | 日韩AV无码专区国产乱码 |