亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国模冰莲2013肥美人体自慰w,国产精品一区在线麻豆
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-NR1H4/AP Conjugated antibody (bs-12867R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-12867R-AP
英文名稱 Rabbit Anti-NR1H4/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的膽汁酸受體抗體
別    名 Bile Acid Receptor NR1H4; BAR; FXR; Farnesoid X activated receptor; Farnesoid X receptor; Farnesoid X-activated receptor; Farnesol receptor HRR 1; Farnesol receptor HRR-1; Farnesol receptor HRR1; FXR; HRR 1; HRR1; NR1H4; NR1H4_HUMAN; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor interacting protein 14; Retinoid X receptor-interacting protein 14; RIP 14; RIP14; RXR interacting protein 14; RXR-interacting protein 14.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  信號轉(zhuǎn)導  新陳代謝  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FXR/Bile Acid Receptor NR1H4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.

Function:
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.

Subunit:
eterodimer of NR1H4 and RXR. After activation by agonist binding, interacts with a coactivator, NCOA1 or NCOA2 (By similarity). Interacts with CARM1 and SMARD1.

Subcellular Location:
Nucleus.

Post-translational modifications:
Methylation may increase transactivation of target genes.

Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 9971 Human

Entrez Gene: 20186 Mouse

Entrez Gene: 60351 Rat

Omim: 603826 Human

SwissProt: Q96RI1 Human

SwissProt: Q3V1T8 Mouse

SwissProt: Q60641 Mouse

SwissProt: Q5XI75 Rat

SwissProt: Q62735 Rat

Unigene: 282735 Human

Unigene: 3095 Mouse

Unigene: 42943 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
老湿地影视体验区 | 国产亚洲欧美成人久久片 | 国产一区二区三区在线看片 | 国产成人综合精品久久 | 国产91精品太粉嫩高中在线观看 | 狠狠色丁香婷婷久久综合五月 | 免费精品国产自产拍在线观看图片 | 国产人人怕人人干视频 | 蜜桃视频一区二区 | 欧美乱色伦图片区小说 | 大又大又粗又硬又爽少妇毛片 | 榴莲视频在线看一日韩 | 日本花心黑人hd捆绑 | 日本欧美一区二区三区片 | 欧美性XXXX潮喷图片 | 性妇WBBBB搡BBBB嗓1 | 未满岁18禁止在线www直播 | 国产日韓无码一区二区三区久久区 | 亚洲国产欧美日韩成人综合 | 爆乳3把你榨干哦OVA在线观看 | 免费一级欧美片片线观看 | 久久久精品久久久久久久久久久 | 欧美精品视频一区二区三区不卡 | 人妻体内射精一区二区三四 | 加勒比高清无码二区在线三级免费电影dvd | 国产猛男猛女超爽免费视频 | 国产亚洲欧美日本一二三本道 | 日本VS亚洲VS韩国一区三区四区 | 99国产一区二区三区亚洲一区影院午夜 | 中文字幕精品一区二区精品 | 男人靠女人的免费视频 | 亚洲精品免费在线 | 乱码视频午夜在线观看 | 九九热这里只有国产精品 | 99久久精品免费看国产一区二区三区 | 黄色毛片视频免费 | 国产又粗又猛又爽又黄的视频免费软件 | 一区二区三区在线观看视频 | 一级毛片视频免费观看 | 国产AV电影区二区三区曰曰骚网 | 精品一级毛片免费视频 |