亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
少妇被躁爽到高潮无码人狍大战,无码人妻免费一区二区三区,91亚洲一区二区三区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-BOB1/AP Conjugated antibody (bs-12876R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12876R-AP
英文名稱 Rabbit Anti-BOB1/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的B淋巴細胞特異性激活OCT結合蛋白1抗體
別    名 B cell Oct binding protein 1; B cell specific coactivator OBF 1; B cell specific coactivator OBF1; B-cell-specific coactivator OBF-1; BOB 1; BOB-1; OBF 1; OBF1; OBF1_HUMAN; OCA B; OCA-B; OCAB; OCT binding factor 1; OCT-binding factor 1; POU domain class 2 associating factor 1; POU domain class 2-associating factor 1; POU2AF1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  轉錄調節(jié)因子  b-淋巴細胞  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BOB1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables them to adopt various monomer configurations on DNA. The versatility of POU protein operation is additionally conferred at the dimerization level. The POU dimer from the OCT1 gene formed on the palindromic OCT factor recognition element, or PORE (ATTTGAAATGCAAAT), could recruit the transcriptional coactivator OBF1. Studies of tissue-specific expression of immunoglobulin promoters demonstrate the importance of an octamer, ATTTGCAT, and the proteins that bind to it. This is a regulatory element important for tissue- and cell-specific transcription as well as for transcription of a number of housekeeping genes. Oct-1 encodes one protein, NF-A1, which is found in nuclear extracts from all cell types and thus is not specific to lymphoid cells as is the protein NF-A2, which is encoded by Oct-2. A novel protein designated Bob 1 (B cell Oct binding protein 1), alternatively called OBF-1, specifically interacts with Oct-1 and Oct-2, enhancing their transcriptional efficacy. Bob 1 is expressed at highest levels in spleen and peripheral blood leukocytes and represents an Oct co-factor capable of conferring cell-specific activation of Oct-1 and Oct-2. Although having no intrinsic capacity for DNA binding, Bob 1 associates tightly with the octamer motif in the presence of Oct-1 and/or Oct-2. The gene which encodes Bob 1 maps to human chromosome 11q23.1.

Function:
Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.

Subcellular Location:
Nucleus.

Tissue Specificity:
B-cell specific.

Post-translational modifications:
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

DISEASE:
Note=A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.

Similarity:
Belongs to the POU2AF1 family.

Database links:

Entrez Gene: 451537 Chimpanzee

Entrez Gene: 528475 Cow

Entrez Gene: 489413 Dog

Entrez Gene: 101129955 Gorilla

Entrez Gene: 100070302 Horse

Entrez Gene: 5450 Human

Entrez Gene: 100394635 Marmoset (common)

Entrez Gene: 100437190 Orangutan

Omim: 601206 Human

SwissProt: Q2KJA4 Cow

SwissProt: Q16633 Human

Unigene: 654525 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
日韩欧美视频一区二区 | 精品久久久久久无码中文字幕动漫 | 2021av一二三级视频在线观看亚洲 | 亚洲 欧美 自拍 美腿 卡通 | 草莓黄瓜蜜桃视频app下载 | 特级av一级毛片乱中年女人伦 | 国产一级a毛一级a做免费图片 | 黄乱色伦短篇小说 | 日韩Av无码久久一区二区 | 久久这里只有精品1 | 午夜性色一区二区三区不卡视频 | 视频在线观看一区 | 91人妻无码精品一区二区毛片 | 中文字幕久久熟女蜜桃 | 好男人好资源官网在线观看 | 中文字幕亚洲精品乱码APP | 国产AⅤ精品一区二区三区久久 | 91精品国产福利资源在线观看麻豆 | 九九热视频精品在线观看 | 国产东北三老头伦一肥婆 | 欧美激情成a人在线观看 | 日韩成人在线视频 | 小骚妇下面水多要插视频 | 美女扒开内裤羞羞网站 | 少妇被躁爽到高潮无码麻豆AV | 特黄三级又爽又粗又大 | 国产乱妇乱子视频在播放 | 国精产品一区二区三区有限公司 | 最近韩国日本免费高清观看 | 18岁日韩内射颜射午夜久久成人 | 国产AVXXXX无套内射 | 老师奶头好大我要摸视频 | 国产在线观看99 | 无码一区18禁3D | 国产美女69视频免费观看 | 欧美35页视频在线观看 | 最新亚洲中文字幕一区在线 | 久久婷婷五月国产色综合 | 91av免费观看| 最近2019中文字幕免费直播 | 婷婷久久综合九色综合伊人色 |