亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
亚洲高清在线精品一区,嗯好湿用力的啊c进来动态图,中文韩国日本免费不卡五月天成人
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-CK18(Ser52)/BF350 Conjugated antibody (bs-12921R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-12921R-BF350
英文名稱 Rabbit Anti-phospho-CK18(Ser52)/BF350 Conjugated antibody
中文名稱 BF350標記的磷酸化細胞角蛋白18抗體
別    名 Cytokeratin 18 (phospho S52); p-Cytokeratin 18 (phospho S52); Cell proliferation inducing gene 46 protein; Cell proliferation inducing protein 46; Cell proliferation-inducing gene 46 protein; CK 18; CK-18; CK18; CYK 18; CYK18; Cytokeratin 18; Cytokeratin endo B; Cytokeratin-18; Cytokeratin18; K 18; K18; K1C18_HUMAN; Keratin 18; Keratin D; Keratin type I cytoskeletal 18; keratin, type I cytoskeletal 18; Keratin-18; Keratin18; Kerd; KRT18.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat, 
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from mouse CK18 around the phosphorylation site of Ser52 [SR(p-S)VW]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].

Function:
When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Subunit:
Heterotetramer of two type I and two type II keratins. KRT18 associates with KRT8. Interacts with the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD.

Subcellular Location:
Cytoplasm, perinuclear region. Nucleus, nucleolus.

Tissue Specificity:
Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

Post-translational modifications:
Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.
O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.

DISEASE:
Defects in KRT18 are a cause of cirrhosis (CIRRH) [MIM:215600].

Similarity:
Belongs to the intermediate filament family.

Database links:

Entrez Gene: 506480 Cow

Entrez Gene: 3875 Human

Entrez Gene: 16668 Mouse

Entrez Gene: 294853 Rat

Omim: 148070 Human

SwissProt: P05783 Human

SwissProt: P05784 Mouse

SwissProt: Q5BJY9 Rat

Unigene: 406013 Human

Unigene: 22479 Mouse

Unigene: 103924 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
忍不住亲子性行为中文字幕 | 中文字幕日韩欧美一区二区三区 | 四季AV无码免费专区 | 国产综合无码一区二区色蜜蜜 | 色综合久久88色综合天天 | 欧美性爱视频在线播放 | 国产精品一区二区熟女不卡 | 亚洲AV无码国产精品久久久不卡 | 很狠干线观看2021 | 国产69精品久久久久无码小说 | 日韩精品国产另类专区 | 公的大龟慢慢挺进我的体内视频 | 2020精品国产自在现线官网 | 五月天婷亚洲天久久综合网 | 久久91久久91精品免费观看 | 91麻豆国产精品91久久久 | 91欧美人妻白浆喷潮在线不卡 | 欧美日韩一区二区三区人妻 | 午夜免费福利小电影 | 国产狂喷水潮免费网站www | 波多野结喷水最猛一部352 | 亚洲国产精品成人AV无码久久综合网 | 女网址www女视频 | 人体内射精一区二区三区 | 日韩精品区一区二区三VR | 午夜精品久久久久久影视riav | 91久久国产最好的精华液 | 五月天综合网缴情五月中文 | 最近最新免费手机中文 | 美女用震蛋叫爽的视频95视频 | 欧美人成在线观看ccc36 | 亚洲欧美一区二区三区四区 | 动漫人物自慰喷水网站 | 最好看的最新高清中文视频 | 国产激情久久久久99蜜桃小说 | 久久精品亚洲精品国产欧美 | 大香伊蕉在人线国产最新75 | 999国内精品永久免费视频 | 久久久久国产一级毛片高清板 | 亚洲中文乱码AV网站 | 欧美日韩免费在线 |