亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
欧美精品黄页在线观看大全,黄色网站在线免费观看
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Ubiquitin D/Biotin Conjugated antibody (bs-13006R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-13006R-Bio
英文名稱 Rabbit Anti-Ubiquitin D/Biotin Conjugated antibody
中文名稱 生物素標記的泛素D抗體
別    名 Diubiquitin; FAT10; UBD 3; Ubd; UBD_HUMAN; Ubiquitin D; Ubiquitin like protein FAT10; Ubiquitin-like protein FAT10.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  神經(jīng)生物學  細胞凋亡  細胞分化  淋巴細胞  b-淋巴細胞  新陳代謝  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ubiquitin D
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
FAT10, also designated Ubiquitin D or Diubiquitin, is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin. Each domain contains two cysteines, along with a free C-terminal diglycine motif required for FAT10 conjugate formation. FAT10 is inducible by interferon-g and tumor necrosis factor a (TNF?). The FAT10 protein interacts with MAD2, a component of the spindle checkpoint, and plays a role in antigen presentation, cytokine response, apoptosis and mitosis. It may also regulate cell growth during dendritic cell or B cell activation and development. FAT10 mRNA is expressed mainly in some dendritic cells and lymphoblastoid lines and in other specific cells subsequent to interferon-g induction. The human FAT10 gene, designated UBD, maps to chromosome 6p21.3 and is overexpressed in the tumors of various epithelial cancers.

Function:
Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).

Subcellular Location:
Nucleus. Cytoplasm. Accumulates in aggresomes under proteasome inhibition conditions.

Tissue Specificity:
Constitutively expressed in mature dendritic cells and B cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland.

Post-translational modifications:
Can be acetylated.

Similarity:
Contains 2 ubiquitin-like domains.

Database links:

Entrez Gene: 10537 Human

Entrez Gene: 24108 Mouse

Omim: 606050 Human

SwissProt: O15205 Human

SwissProt: P63072 Mouse

Unigene: 44532 Human

Unigene: 140210 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
麻豆一区二区免费播放网站 | 人妻无码专区一专区二专区三 | 在线免费观看三级片国产 | 中文国产成人AⅤ久久 | 爆乳护士一区二区三区在线播放 | 国产麻豆一区二区三区精品视频 | 91无码人妻精品一区 | 欧美国产一区二区三区激情无套 | 久久精品国产欧美日韩99热 | 一本大道加勒比久久 | 九九综合VA免费看 | 在线观看免费国产视频 | 超级乱淫小黄文小说 | 午夜亚洲乱码伦小说区69堂 | 青春草无码精品视频在线观看 | 99久久精品国产第一页 | 亚洲国产成人精品刺激内射白浆 | 2021av一二三级视频在线观看亚洲 | 性欧美video另类hd尤物 | 男人的天堂无码Av色偷偷 | 欧美精品黄网站在线播放 | 欧美综合区自拍亚洲综合天堂 | 性妇WBBBB搡BBBB嗓小说 | 午夜精品久久久久久影视riav | 精品国产乱码久久久EA7 | 成片人免费观看一级A片 | 久久刺激cijilu福利72 | 亚洲人妻少妇av资源网站 | 欧美人妻少妇精品视频专区 | 国产萌白酱在线一区二区 | 国产福利在线免费 | 超碰国产精品人人做人人爱 | 欧美大片AAAAA免费观看 | 我们日本在线观看免费动漫下载 | 奇米成人影院777欧美极品 | 欧美性一交一乱一伦A片 | 双飞风韵犹存两个熟妇 | 国产AV无码国产AV毛片 | 亚洲精品欧美精品中文字幕 | 欧美日韩一区精品高免费专区 | 性饥渴艳妇K8经典色欲 |