亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線(xiàn):400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
一级黄色香蕉视频,2021国产麻豆剧传媒免费下载,麻豆蜜桃国产精品无码视频
Rabbit Anti-MHC Class II/PE Conjugated antibody (bs-8481R-PE)
訂購(gòu)熱線(xiàn):400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-8481R-PE
英文名稱(chēng) Rabbit Anti-MHC Class II/PE Conjugated antibody
中文名稱(chēng) PE標(biāo)記的組織相容性復(fù)合體蛋白2抗體
別    名 DMA; DMB; DRB; HLA class II histocompatibility antigen DM beta chain; HLA DMB; HLADM; HLADP1B; Major histocompatibility complex clas; HLA class II histocompatibility antigen, DM beta chain; MHC class II antigen DMB; Really interesting new gene 7 protein; HLA-DMB; RING7; DMB_HUMAN; MHC2.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞分化  細(xì)胞類(lèi)型標(biāo)志物  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HLA class II histocompatibility antigen DM beta chain
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
MHC Class II antigens are heterodimers consisting of one alpha chain (31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.

Function:
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Subunit:
Heterodimer of an alpha chain (DMA) and a beta chain (DMB).

Subcellular Location:
Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus > trans-Golgi network membrane. Endosome membrane. Lysosome membrane. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Similarity:
Belongs to the MHC class II family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 3109 Human

Omim: 142856 Human

SwissProt: P28068 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲色欲色欲WWW成人网麻豆 | 亚洲无线一二三四区手机 | 国产精品免费大片 | 欧美日韩免费播放一区二区 | 欧美精品久久久久久久小说 | 国产精品久免费的黄网站 | 免费的人成黄网站在线观看视频 | 日韩青草青草久热精品视频在线网站乱码 | 一木道一二三区精品 | 五月丁香综合缴情六月 | 超碰97久久久久久久久久久 | 色欲av伊人久久大香线蕉影院 | 欧美精品人人做天天操夜夜操 | 特黄三级又爽又粗又大洗澡 | 国产乱码精品一区二区三区中文 | 久久综合亚洲鲁鲁五月天 | 最近免费中文字幕大全高清大全1 | 午夜福利一区二区三区在线观看 | 精品21国产成人综合网在线 | 18禁黄网站禁片免费观看久久 | 久久综合色天天久久综合图片 | 久久久久久高清毛片一级 | 大学生高潮无套内谢视频 | 公么大龟弄得我好舒服秀婷视频 | 亚洲日韩精品A∨在线观看 欧美a∨亚洲欧美亚洲 | 国产真实女人一级毛片 | 巜豪妇荡乳2在线观看 | 女性高爱潮AAAA级视频免费 | 搡老熟女老女人一区二区三区 | 999在线视频精品免费播放观看 | 香港三级精品三级在线专区 | 精品一卡2卡三卡4卡乱码毛1 | www.高潮原创av| 国产 浪潮AV性色四虎 | 在线精品自偷自拍无码 | 欧美bbbbbxxxxx | 99热门精品一区二区 | 黄网站在线观看高清免费 | 国产精品久久久久精品一级APP | moneses性欧美 | 国产精品99久久久久久 |