亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
日本乱人伦aⅴ精品潮喷,久久亚洲美日韩精品无码一区二区
Rabbit Anti-Phospho-HDAC5 (Ser259)/BF647 Conjugated antibody (bs-10326R-BF647)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-10326R-BF647
英文名稱 Rabbit Anti-Phospho-HDAC5 (Ser259)/BF647 Conjugated antibody
中文名稱 BF647標(biāo)記的磷酸化組蛋白去乙?;?抗體
別    名 HDAC5 (phospho S259); p-HDAC5 (phospho S259); HDAC5(Phospho-Ser259); HDAC5(Phospho-S259); p-HDAC5(Ser259); p-HDAC5(S259); HD 5; HD5; HDAC 5; Histone deacetylase 5; KIAA0600; NY CO 9; Antigen NY CO 9; FLJ90614; HDAC5_HUMAN; Antigen NY-CO-9.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 123kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human HDAC5 around the phosphorylation site of Ser259
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.

Subunit:
Interacts with AHRR. Interacts with BAHD1, BCOR, HDAC7, HDAC9, CTBP1, MEF2C, NCOR2, NRIP1, PHB2 and a 14-3-3 chaperone protein. Interacts with KDM5B. Interacts with MYOC. Interacts with GRK5. Interacts with DDIT3/CHOP.

Subcellular Location:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated by AMPK, CaMK1, SIK1 and PRKD1 at Ser-259 and Ser-498. The phosphorylation is required for the export to the cytoplasm and inhibition. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylated by GRK5, leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription.
Ubiquitinated. Polyubiquitination however does not lead to its degradation.

Similarity:
Belongs to the histone deacetylase family. HD type 2 subfamily.

Database links:

Entrez Gene: 10014 Human

Entrez Gene: 15184 Mouse

Entrez Gene: 84580 Rat

Omim: 605315 Human

SwissProt: Q9UQL6 Human

SwissProt: Q9Z2V6 Mouse

Unigene: 438782 Human

Unigene: 22665 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产一区二区高清 | 成人免费毛片内射美女APP | 好舒服好粗好硬免费视频 | 12一14性xxxxx国外 | 影音先锋av男人资源 | 午夜无码片在线观看影院 | 五月丁香久久伊人本道开心 | 蜜桃精品免费久久久久影院 | 久久精品一区二区国产 | 国产喷水1区2区3区咪咪爱AV | 亚洲精品国产高清不卡在线 | 欧美午夜艳片欧美精品 | 99久久国产精品亚洲综合看片 | 成年女人毛片免费播放视频m | 人人超碰人人爽人人添 | 国产精品视频一区二区三区不卡 | 久久精品99国产精品日本 | 国产精品一区二区熟女不卡 | 美女被抽插到哭内射视频免费 | 品产品久精国精产拍20 | 又黄又猛又爽大片免费 | 搡老熟女老女人一区二区三区 | 含羞草实验研所传媒网站进入 | 久久久精品国产亚洲AV综合 | 99热精品国产三级在线 | 软糯白嫩双性受h | 狠狠躁18三区二区一区 | 性一交一无一伦一精一品 | 国产成a人大片在线观看 | 国产精品看高国产精品不卡 | 欧美一级特黄乱妇高清视频 | 国产精品免费视频一区二区三区 | 色久综合网精品一区二区 | 内射人妻无码色AV | 精品国产粉嫩内射白浆内射双马尾 | 亚洲午夜成激人情在线影院 | 精产国蘑菇品一二三产品区 | 日韩精品成人av高清在线观看 | 99国产亚洲精品无码成人69V | 亚洲中文久久精品中文字幕 | 欧美人妻中文字幕乱码在线 |