亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美激情性A片在线观看,久久婷婷97人妻无码狠狠综合久久久久综合
Rabbit Anti-IFI16/RBITC Conjugated antibody (bs-15548R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-15548R-RBITC
英文名稱 Rabbit Anti-IFI16/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的Gamma干擾素誘導(dǎo)蛋白16抗體
別    名 IFI16; Gamma interferon inducible protein 16; Gamma-interferon-inducible protein Ifi16; IF16_HUMAN; Ifi204; IFNGIP1; interferon activated gene 204; Interferon gamma induced protein IFI 16; Interferon gamma inducible protein 16; Interferon-inducible myeloid differentiation transcriptional activator; p204; PYHIN2.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  新陳代謝  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 88kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IFI16
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
IFI16 is a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Function:
Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors.

Subunit:
Forms homooligomers; isoform 2 can self-associate or associate with isoform 1 or isoform 3. Interacts with TMEM173, AIM2, PYCARD and CASP1. Interacts with BRCA1, TP53, E2F1, RB1 and SP1.

Subcellular Location:
Nucleus. Cytoplasm. Note=Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization.

Tissue Specificity:
Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level).

Post-translational modifications:
Lysine acetylation in the multipartite nuclear localization signal (NLS) regulates the subcellular location. In vitro can be acetylated by p300/EP300 coupled to cytoplasmic localization.
Phosphorylated on Ser and Thr.
Isoform 3 seems to show a minor degree of complex carbohydrate addition.

Similarity:
Belongs to the HIN-200 family.
Contains 1 DAPIN domain.
Contains 2 HIN-200 domains.

Database links:
UniProtKB/Swiss-Prot: Q16666.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
在线视频精品免费 | 一级毛片视频免费观看 | 加勒比高清无码二区在线三级免费电影dvd | 久久久久亚洲AV成人人人 | 亚洲高清成人AV电影网站 | 91麻豆精品国产一级 | 欧美成人一区二区三区在线视频 | 粗大的内捧猛烈进出视频网 | 日韩精品午夜视频一区二区三区 | 日韩精品欧美在线视频在线 | BBB搡BBBB搡BBBB | 国产亚洲AV片在线观看16女人 | 亚洲AV中文无码字幕色三 | 国产精品xxxav免费视频 | 嫦娥仙子含精肉臀迎合 | 久青青在线观看视频国产 | 国产欧美一区二区精品久久久 | 久久久久久久精品国产亚洲蜜臀 | 国产午夜片无码区在线观看爱情网 | 亚洲综合另类欧美久久久久精品 | 搡老熟女老女人一区二区三区 | 50岁老熟女露脸25分钟91 | 宝贝别忍着喷出来嗯啊哦漫画 | 欧美午夜艳片欧美精品 | 国产二级一片内射视频插放 | 色偷偷偷久久伊人大杳蕉 | 美女黄色在线网站大全 | 被同桌摸出水来了好爽的视频 | 456性欧美在线播放 亚洲最大成人综合网720P | 欧美精品成人一区二区在线观看 | 在线视频一区二区三区不卡 | 精品人妻少妇一级毛片免费 | 91大神视频在线播放 | 特级毛片在线大全免费播放 | 337p日本欧洲亚洲大胆 | 国产激情艳情在线看视频 | 妖精视频一区二区免费 | 亚洲中文字幕精品久久app | 美女性爽视频国产免费 | 国内久经典AAAAA片 | 一本久久a久久精品亚洲 |