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Rabbit Anti-DLL1/BF488 Conjugated antibody (bs-7345R-BF488)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-7345R-BF488
英文名稱 Rabbit Anti-DLL1/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的Notch信號(hào)通路Delta樣配體1抗體
別    名 Delta (Drosophila) like 1; Delta; Delta like 1 (Drosophila); Delta like 1; Delta like 1 protein; Delta like protein 1; Delta like protein 1 precursor; Delta, Drosophila, homolog of 1; Delta-like protein 1; Delta1; DL1; DLL 1; Dll1; DLL1_HUMAN; Drosophila Delta homolog 1; H-Delta-1; OTTHUMP00000017690.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  淋巴細(xì)胞  b-淋巴細(xì)胞  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Chicken, Cow, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 76kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DLL1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. Delta is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis, and in adult heart and lung.

Function:
Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

Subunit:
Interacts with Notch receptors.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Post-translational modifications:
Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.

Similarity:
Contains 1 DSL domain.
Contains 8 EGF-like domains.

Database links:

Entrez Gene: 28514 Human

Entrez Gene: 13388 Mouse

Entrez Gene: 84010 Rat

Omim: 606582 Human

SwissProt: O00548 Human

SwissProt: Q61483 Mouse

SwissProt: P97677 Rat

Unigene: 379912 Human

Unigene: 4875 Mouse

Unigene: 10628 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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