亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
放荡的小峓子2中文字幕,成人免费精品网站在线观看影片
Rabbit Anti-Rasgrp1/RBITC Conjugated antibody (bs-10436R-RBITC)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-10436R-RBITC
英文名稱 Rabbit Anti-Rasgrp1/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的Ras蛋白特異鳥(niǎo)嘌呤核苷酸釋放因子1抗體
別    名 Calcium and DAG-regulated guanine nucleotide exchange factor II; CALDAG-GEFI; CALDAG-GEFII; Guanine nucleotide exchange factor, calcium and DAG regulated, Rap1A; hRasGRP1; Ras activator RasGRP; RAS guanyl nucleotide releasing protein 1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); RAS guanyl releasing protein 1; RASGRP; RASGRP1; GRP1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  結(jié)合蛋白  G蛋白偶聯(lián)受體  G蛋白信號(hào)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 90kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Rasgrp1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].

Function:
RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas.

Subunit:
Forms a signaling complex with DGKZ and HRAS. Interacts with F-actin. Interacts with SKAP1.

Subcellular Location:
Cell Membrane, Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus. Found in membrane fraction. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor.

Tissue Specificity:
Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level).

Post-translational modifications:
Defects in RASGRP1 may contribute to susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.

Similarity:
Belongs to the RASGRP family.
Contains 2 EF-hand domains.
Contains 1 N-terminal Ras-GEF domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Ras-GEF domain.

Database links:

Entrez Gene: 10125 Human

Entrez Gene: 19419 Mouse

Omim: 603962 Human

SwissProt: O95267 Human

SwissProt: Q9Z1S3 Mouse

Unigene: 591127 Human

Unigene: 42150 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产精品看高国产精品不卡 | 性一交一无一伦一精一品视频 | 浪荡女天天不停挨CAO日常视频 | 熟女少妇一区二区中文字幕 | 国产婷婷色综合AV蜜臀AV | 无码人妻精品中文字幕 | 91免费精品国自产拍在线可以看 | 无码AV大香线蕉伊人久久九色 | 欧美激情一区二区 | 大乳熟女中文字幕久久 | 国产黄A三级三级三级看三级 | 亚洲无码总合另类中文字幕 | 国产一级 片内射免费视频播放 | 老司机无码精品A | 亚洲国产精品特色大片观看完整版 | 在线视频一区二区三区在线播放 | 久久91精品国产91久 | 亚洲成AV人片一区二区不卡 | 亚洲国产精品午夜福利在线观看 | 黑人上司粗大拔不出来 | 国内久经典AAAAA片 | 人妻无码专区一专区二专区三 | 中文毛片无遮挡高潮免费 | 国产成人午夜精品5599 | 亚洲AV无码久久久久久精品酒店 | 亚1州区2区3区4区产品图片 | 久久久久成人精品亚洲国产av综合 | 亚洲中文字幕无码一久久区 | 99成人在线观看 | 久久久91精品国产一区二区 | 国产午夜精品片一区二区三区 | 日韩一区二区三区射精 | 大学生高潮无套内谢视频 | 无码av中文字幕免费放 | 蜜臀AV一区二区三区人妻在线 | 男人TV天堂精品一区二区 | 男人天堂·手机版在线 | 热久久国产欧美一区二区精品 | 精品国产一区二区三区AV性色 | 国产99精品在线观看 | 中文字幕在线免费观看视频 |