亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
综合精品欧美日韩在线观看,国产欧美精品一区二区三区-老狼,九九视频精品全部免费播放
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-TRIP12/FITC Conjugated antibody (bs-17129R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-17129R-FITC
英文名稱 Rabbit Anti-TRIP12/FITC Conjugated antibody
中文名稱 FITC標記的甲狀腺激素受體相互作用12抗體
別    名 KIAA0045; MGC138849; MGC138850; Thyroid hormone receptor interactor 12; Thyroid receptor interacting protein 12; TRIP 12.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 220kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRIP12
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
TRIP12 (thyroid hormone receptor interactor 12) is an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. TRP12 specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). TRP12 was originally identified as a factor that interacts with the thyroid hormone receptor. It was later found to also interact with AAP-BP1, a component of the NEDD8 –activating enzyme, and function as an E3 ubiquitin ligase for AAP-BP1.

Function:
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

Subunit:
Interacts with MYC; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with TRADD; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with SMARCC1; leading to disrupt interaction with SMARCE1.

Subcellular Location:
Nucleus, nucleoplasm

Similarity:
Belongs to the UPL family. K-HECT subfamily.
Belongs to the UPL family. K-HECT subfamily.
Belongs to the UPL family. K-HECT subfamily.


Database links:

Entrez Gene: 9320 Human

Omim: 604506 Human

SwissProt: Q14669 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产精品丰满无码理论片 | 成年入口无限观看免费完整大片 | 亚洲日本久久久午夜精品 | 精品国产成人亚洲午夜福利 | 天天躁日日躁狠狠躁欧美 | 黄区1区2区3区4区5区 | 久久久久国产一级毛片高清板 | 含羞草实验研所传媒网站进入 | 印度一级特黄AAAAAA片在线看 | 免费一级毛片私人影院a行 99精产国品一二三产 | 忘忧草日本在线播放WWW | 一级a性色生活片久久毛片 日韩欧美一中文字慕2O22 | 麻豆国产AV尤物网站尤物 | 色伦专区97中文字幕 | 日韩欧美一及在线播放 | 欧美1区2区3区 | 国产成a人片在线观看视频 女人赤裸裸正面下身照片 女人脱精光让人桶爽了 | 久久精品国产a真人一级无码毛片一区二区 | 性色AV一区二区三区V视界影院 | 一级做a爰片久久免费 | 欧美一区二区三区久久综 | 不卡高清AV手机在线观看 | 二区久久久国产AV色 | 精品无码国产拍自产拍在线 | 中国一级毛片在线观看 | 国产一区在线观看免费 | 成 人 免 费 黄 色 网站无毒下载 | 成全视频在线观看免费高清版 | 在线中文字幕亚洲第一 | 青春禁区在线观看免费 | 少妇高潮一区二区三区99 | 伊人久久大香线蕉亚洲五月天 | 米奇奇米777第四色 国产精品免费大片 | 性xxxxbbbb免费播放视频 | 国产成人精品免费久久久久 | 久久精品国产免费中文 | 日欧精品卡2卡3卡4卡5卡L | 国产乱码精品一品二品 | 久久综合九色综合欧美久久久 | 污污又黄又爽免费的网站 | 日韩一区二区在线观看视频 |