亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
综合精品欧美日韩在线观看,国产欧美精品一区二区三区-老狼,九九视频精品全部免费播放
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-TRIP12/FITC Conjugated antibody (bs-17129R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-17129R-FITC
英文名稱 Rabbit Anti-TRIP12/FITC Conjugated antibody
中文名稱 FITC標記的甲狀腺激素受體相互作用12抗體
別    名 KIAA0045; MGC138849; MGC138850; Thyroid hormone receptor interactor 12; Thyroid receptor interacting protein 12; TRIP 12.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 220kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRIP12
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
TRIP12 (thyroid hormone receptor interactor 12) is an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. TRP12 specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). TRP12 was originally identified as a factor that interacts with the thyroid hormone receptor. It was later found to also interact with AAP-BP1, a component of the NEDD8 –activating enzyme, and function as an E3 ubiquitin ligase for AAP-BP1.

Function:
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

Subunit:
Interacts with MYC; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with TRADD; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with SMARCC1; leading to disrupt interaction with SMARCE1.

Subcellular Location:
Nucleus, nucleoplasm

Similarity:
Belongs to the UPL family. K-HECT subfamily.
Belongs to the UPL family. K-HECT subfamily.
Belongs to the UPL family. K-HECT subfamily.


Database links:

Entrez Gene: 9320 Human

Omim: 604506 Human

SwissProt: Q14669 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
我两腿被同学摸的直流水 | 把手戳进美女尿口里动态图 | 久久精品国产精品亚洲色婷婷 | 乱码一二三乱码又大又粗 | 成人国产欧美大片一区 | 欧美a∨亚洲欧美亚洲 | 国产精品视频一区二区三区无码 | 久久九九日本韩国精品 | 成人免费无码精品国产电影WWW | 一色屋精品亚洲香蕉网站 | 欧美精品在线观看视频 | 内射人妻精品丨色AV无码 | 2021年日本中文字幕在线 | 成人网站免费大全日韩国产 | 亚洲国产精品成人AV无码久久综合网 | 又粗又大又黄的少妇毛片 | 精品久久久久久无码不卡 | 高潮毛片无遮挡免费高清 | 亚洲AV无码乱码国产精品久久 | 国产精品无码免费专区午夜 | 校花被惩罚下面放震蛋上课视频 | 亚洲精品国产A久久久久久 91手机在线视频观看 | 国产精品久久久久久无码 | 91精品国产色综合久久 | 中文字幕久久久久久一区二区三区 | 欧美性一交一乱一伦A片 | 艳妇臀荡乳欲伦69调教视频 | 男女激情射精国产精品久久 | 午夜三级a三级三点窝558888 | 内射人妻无码色AV麻豆 | 在线中文字幕亚洲第一 | 人妻精品久久久久中文字幕69 | 99视频30精品视频在线观看 | 内射国产老熟女综合导航 | 久久蜜臀av色欲免费看 | 最近免费中文字幕MV免费高清 | 亚洲AⅤ日韩久久久久久 | 日本工口里番H彩色无遮挡全彩 | 她的丝袜脚胯下圣水尿 | 牝教师4~秽された教坛~第6集 | 国产精品日本欧美一区二区 |