亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
一女侍七夫巨H双修,亚洲国产精品一区二区三区在线观看,成年网站免费人性视频a站
Rabbit Anti-TRIP12/PE-Cy5 Conjugated antibody (bs-17129R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-17129R-PE-Cy5
英文名稱 Rabbit Anti-TRIP12/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的甲狀腺激素受體相互作用12抗體
別    名 KIAA0045; MGC138849; MGC138850; Thyroid hormone receptor interactor 12; Thyroid receptor interacting protein 12; TRIP 12.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  表觀遺傳學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 220kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRIP12
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
TRIP12 (thyroid hormone receptor interactor 12) is an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. TRP12 specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). TRP12 was originally identified as a factor that interacts with the thyroid hormone receptor. It was later found to also interact with AAP-BP1, a component of the NEDD8 –activating enzyme, and function as an E3 ubiquitin ligase for AAP-BP1.

Function:
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

Subunit:
Interacts with MYC; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with TRADD; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with SMARCC1; leading to disrupt interaction with SMARCE1.

Subcellular Location:
Nucleus, nucleoplasm

Similarity:
Belongs to the UPL family. K-HECT subfamily.
Belongs to the UPL family. K-HECT subfamily.
Belongs to the UPL family. K-HECT subfamily.


Database links:

Entrez Gene: 9320 Human

Omim: 604506 Human

SwissProt: Q14669 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产欧美日韩精品视频一区二区三区 | 国产日韩欧美三级 | 欧美亚洲另类日韩图片区 | 好紧好爽好疼的免费视频全集完整版在线播放 | 醉酒后少妇被疯狂内射视频 | 亚洲精品不卡午夜精品 | 精产国品一区二区三产区 | 狠狠躁夜夜躁人人爽天天69 | 18成人片黄网站WWW | 国产又湿又黄又硬又刺激视频 | 国产最新一区二区三区天堂 | 九色91精品国产网站 | 97超级碰碰碰久久久久总站 | 无人在线观看视频高清视频8 | 91精品国产91久久综合 | 伊人久久大香线蕉综合色狠狠 | 成年免费视频黄网站在线观看 | 性色AV一区二区三区V视界影院 | 国产无遮挡又黄又爽在线视频 | 伊人久久大香线蕉综合色狠狠 | 色婷婷狠狠18禁久久 | 国产精品久久久久久久久久免费 | 日本少妇AA一级特黄大片 | 久久久久久久高清内射日韩 | 又湿又紧又大又爽又A视频 一二三四社区在线中文视频 | 免费无码片国产在线观看 | 日韩精品区一区二区三VR | 美女网站在线观看视频18 | 亚洲a片无码一区二区蜜桃久久 | 爽到高潮无码视频在线观看 | 一个人免费观看视频www | 欧美一级又粗又大又黑 | 性色AV一区二区三区V视界影院 | 国产网址在线观看 | 18成禁人视频免费午夜影视 | 公的大龟慢慢挺进我的体内视频 | 国产99在线视频 | 男JI大巴进入女人的视频 | 97精品国产高清久久久久 | 国产精品福利在线播放 | 欧美日韩乱国产无遮挡 |