亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
国产一区二区无码蜜芽精品,精品日本亚洲一区二区三区
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-TRIP12/BF647 Conjugated antibody (bs-17129R-BF647)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-17129R-BF647
英文名稱 Rabbit Anti-TRIP12/BF647 Conjugated antibody
中文名稱 BF647標記的甲狀腺激素受體相互作用12抗體
別    名 KIAA0045; MGC138849; MGC138850; Thyroid hormone receptor interactor 12; Thyroid receptor interacting protein 12; TRIP 12.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 220kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRIP12
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
TRIP12 (thyroid hormone receptor interactor 12) is an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. TRP12 specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). TRP12 was originally identified as a factor that interacts with the thyroid hormone receptor. It was later found to also interact with AAP-BP1, a component of the NEDD8 –activating enzyme, and function as an E3 ubiquitin ligase for AAP-BP1.

Function:
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

Subunit:
Interacts with MYC; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with TRADD; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with SMARCC1; leading to disrupt interaction with SMARCE1.

Subcellular Location:
Nucleus, nucleoplasm

Similarity:
Belongs to the UPL family. K-HECT subfamily.
Belongs to the UPL family. K-HECT subfamily.
Belongs to the UPL family. K-HECT subfamily.


Database links:

Entrez Gene: 9320 Human

Omim: 604506 Human

SwissProt: Q14669 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产毛多水多高潮高清 | 91传媒无码一级精品片 | 国产精品久久久天天影视香蕉 | 最近中文字幕免费国语 | 黄色视频免费在线观看 | 欧美精品一区二区在线观看播放 | 久久另类精品欧美日韩高清精品不卡 | 黑人啊灬啊灬啊灬快灬深 | 老师奶头好大我要摸视频 | 91精品国产高清一区二区三密臀 | 免费国产一级片内射视频 | 99爱在线精品视频免费观看9 | 亚洲日韩在线男人视频网站 | 亚欧成人毛片一区二区三区四区 | 欧美午夜精品一区二区蜜桃 | 亚州一级一片无码内射 | 国产午夜免费视频片夜色 | 色综合久久88色综合天天 | 无码人妻丰满熟妇精品区 | 亚洲熟妇无码久久精品疯 | 国产男人午夜视频在线观看 | 日产粗又猛又爽又黄的视频 | 日韩精品一区二区三区A片 亚洲欧美日韩国产综合五月天 | 一本久久a久久精品免费不卡 | miaa213永濑唯在线观看 | 波多野结衣无码在线观看 | 搡老熟女老女人一区二区三区 | 国产网红在线_电影频道 | 麻豆春药按摩无码AV片 | 国产日韩欧美另类 | 久久亚洲AⅤ精品网站 | 国产亚洲精品中文带字幕21页 | 精品人妻无码中文字幕第一区 | 久久成人无码国产免费播放 | 欧美白人极品性喷潮 | jizz国产丝袜18老师美女 | 欧美性受XXXX黑人XYX性爽 | 2019午夜福利不卡片在线 | 亚洲成人电影在线观看精品国产 | 公的大龟慢慢挺进我的体内视频 | 老司机久久精品最新免费 |