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Rabbit Anti-SP140/Gold Conjugated antibody (bs-17138R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-17138R-Gold
英文名稱 Rabbit Anti-SP140/Gold Conjugated antibody
中文名稱 膠體金標記的核自身抗原SP140抗體
別    名 LY10_HUMAN; Lymphoid restricted homolog of Sp100; Lymphoid specific SP100 homolog; Lymphoid-restricted homolog of Sp100; LYSP100 A; LYSp100; LYSP100 B; LYSp100 protein; LYSP100-A; LYSP100-B; LYSP100A; LYSP100B; MGC126440; Nuclear antigen Sp140; Nuclear autoantigen Sp-140; Nuclear autoantigen Sp140; Nuclear body protein SP140; SP140; SP140 nuclear body protein; SP140 PEN; Speckled 140 kDa.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細胞生物  染色質(zhì)和核信號  轉(zhuǎn)錄調(diào)節(jié)因子  淋巴細胞  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Dog, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SP140
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
SP140 is an 867 amino acid cytoplasmic and nuclear protein that is highly expressed in spleen and peripheral blood leukocytes. SP140 is a component of the nuclear body that may be involved in trafficking between the nucleus and the cytoplasm. SP140 is induced by interferons and contains a bromo domain, a HSR domain, a PHD-type zinc finger and a SAND domain. It is thought that SP140 may participate in the pathogenesis of acute promyelocytic leukemia and viral infection. SP140 is expressed as three isoforms produced by alternative splicing and are designated isoform LYSp100-A, isoform LYSp100-B and isoform SP140.

Function:
Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.

Subunit:
Interacts with PIN1.

Subcellular Location:
Nucleus. Cytoplasm. Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus.

Tissue Specificity:
High levels in spleen and peripheral blood leukocytes, much lower levels in thymus, prostate, ovary, small intestine, and colon. Very low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.

Similarity:
Contains 1 bromo domain.
Contains 1 HSR domain.
Contains 1 PHD-type zinc finger.
Contains 1 SAND domain.

Database links:

Entrez Gene: 11262 Human

Omim: 608602 Human

SwissProt: Q13342 Human

Unigene: 632549 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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