亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
波多野结衣AV在线播放,超碰97人人做人人爱亚洲尤物 ,国产真实女人一级毛片
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-Histone H3 (Thr32)/BF350 Conjugated antibody (bs-17441R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-17441R-BF350
英文名稱 Rabbit Anti-phospho-Histone H3 (Thr32)/BF350 Conjugated antibody
中文名稱 BF350標記的磷酸化組蛋白H3抗體
別    名 Histone H3 (phospho T32); p-Histone H3 (phospho T32); H3 3 like sequence MH921; H3 3 like sequence MH921; H3 3A; H3 a; H3 b; H3 c; H3 d; H3 f; H3 h; H3 histone family member E pseudogene; H3 histone family member E pseudogene; H3 i; H3 j; H3 k; H3 l; H33_HUMAN; H3F3; H3f3b; Histone H3 3 pseudogene; Histone H3 3 pseudogene; Histone H3.3  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領域 細胞生物  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Histone H3 around the phosphorylation site of Thr32
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008]

Function:
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subcellular Location:
Nucleus. Chromosome.

Post-translational modifications:
Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).
Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCBB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.

Similarity:
Belongs to the histone H3 family.

Database links:

Entrez Gene: 326601 Cow

Entrez Gene: 8350 Human

Entrez Gene: 8351 Human

Entrez Gene: 8352 Human

Entrez Gene: 8353 Human

Entrez Gene: 8354 Human

Entrez Gene: 8355 Human

Entrez Gene: 8290 Human

Entrez Gene: 8350 Human

Entrez Gene: 8351 Human

Entrez Gene: 8352 Human

Entrez Gene: 8353 Human

Entrez Gene: 8354 Human

Entrez Gene: 8355 Human

Entrez Gene: 8356 Human

Entrez Gene: 8357 Human

Entrez Gene: 8358 Human

Entrez Gene: 8968 Human

Entrez Gene: 260423 Mouse

Entrez Gene: 319148 Mouse

Entrez Gene: 319149 Mouse

Entrez Gene: 319150 Mouse

Entrez Gene: 319151 Mouse

Entrez Gene: 319152 Mouse

Entrez Gene: 319153 Mouse

Entrez Gene: 360198 Mouse

Entrez Gene: 97908 Mouse

Entrez Gene: 100364501 Rat

Entrez Gene: 100365669 Rat

Entrez Gene: 291159 Rat

Entrez Gene: 314977 Rat

Entrez Gene: 364716 Rat

Entrez Gene: 679950 Rat

Entrez Gene: 679994 Rat

Entrez Gene: 680511 Rat

Entrez Gene: 680599 Rat

Entrez Gene: 682330 Rat

Entrez Gene: 691496 Rat

Omim: 601128 Human

Omim: 602810 Human

Omim: 602811 Human

Omim: 602812 Human

Omim: 602813 Human

Omim: 602814 Human

Omim: 602815 Human

Omim: 602816 Human

Omim: 602817 Human

Omim: 602818 Human

Omim: 602819 Human

SwissProt: P68431 Human

SwissProt: P84243 Human

SwissProt: Q16695 Human

SwissProt: Q6NXT2 Human

SwissProt: Q71DI3 Human

SwissProt: P68433 Mouse

SwissProt: P84228 Mouse

SwissProt: Q6LED0 Rat

Unigene: 132854 Human

Unigene: 247813 Human

Unigene: 247814 Human

Unigene: 248176 Human

Unigene: 443021 Human

Unigene: 484990 Human

Unigene: 532144 Human

Unigene: 533292 Human

Unigene: 546315 Human

Unigene: 586261 Human

Unigene: 591778 Human

Unigene: 221301 Mouse

Unigene: 261657 Mouse

Unigene: 377874 Mouse

Unigene: 390558 Mouse

Unigene: 397328 Mouse

Unigene: 138090 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
手机在线精品视频 | 久久精品中文騷妇女内射 | 又黄又爽又无遮挡在线观看免费 | 欧美日韩精品国产一区在线 | 日韩电影免费在线观看网站 | 天堂中文最新版在线中文 | 永久免费毛片在线播放 | 不卡高清AV手机在线观看 | 亚洲国产精品久久久天堂 | 91人妻无码精品一区二区毛片 | 开心婷婷五月综合基地 | 九九视频免费精品视频免费 | 最近日本MV字幕免费观看视频 | 特级毛片A级毛片免费观看网站 | 欧美体内SHE精视频 亚洲国产天堂久久综合网 在线观看亚洲中文字幕 | 女被男啪到哭的视频网站免费 | 免费精品国产自产拍在线观看图片 | 亚洲AV无码一区二区三区在线高 | 国产精品沙发午睡系列990531 | 2021国产精品视频一区 | 国产伦精品一区二区三区妓女 | 中文字幕看片在线a免费 | 国产2021中文天码字幕 | av在线不卡网站无码18禁 | 亚洲第一免费播放区 | 性成熟黑人双插美国1819 | 女人扒开腿让男人狂桶30分钟 | 国产成人无码区免费内射一片色欲 | 国产成人精品一区二区免费 | 黄色视频软件免费下载 | 国产无遮挡成人免费视频网站 | 内射白浆一区二区在线观看 | 野花视频在线观看高清免费完整版 | 18岁日韩内射颜射午夜久久成人 | 人与禽性伦交在线观看 | 又大又粗进出白浆直流视频在线 | 免费国产黄线在线观看 | A级黄片人人插人人摸 | 最近2019中文字幕免费直播 | 特级无码一区二区三区毛片视频 | 国产精品TV在线麻豆 |