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Rabbit Anti-MMRN2/BF555 Conjugated antibody (bs-17688R-BF555)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-17688R-BF555
英文名稱 Rabbit Anti-MMRN2/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的細(xì)胞外基質(zhì)糖蛋白MMRN2抗體
別    名 Elastin microfibril interface located protein 3; Elastin microfibril interfacer 3; EMILIN-3; EndoGlyx-1 p125/p140 subunit; MMRN2; MMRN2_HUMAN; Multimerin-2.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  糖蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Dog, Horse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 104kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMRN2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]

Function:
Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.

Subunit:
Heteromer of p110, p125, p140 and p200 subunits;disulfide-linked. Interacts with VEGFA.

Subcellular Location:
Secreted > extracellular space > extracellular matrix.

Tissue Specificity:
Endothelium.

Post-translational modifications:
N- and O-glycosylated.

Similarity:
Contains 1 C1q domain.
Contains 1 EMI domain.

Database links:

Entrez Gene: 79812 Human

Omim: 608925 Human

SwissProt: Q9H8L6 Human

Unigene: 524479 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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