亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产精品免费久久久久影院,91人妻无码精品一区二区毛片,一级a一级a爱片免费免免高潮
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-MCM2 (Ser27)/AP Conjugated antibody (bs-18262R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-18262R-AP
英文名稱 Rabbit Anti-phospho-MCM2 (Ser27)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的磷酸化MCM2蛋白抗體
別    名 MCM4 (phospho S27); MCM2(phospho-Ser27); MCM2(phospho Ser27); MCM2 (phospho S27); p-MCM2(Ser27); p-MCM2(S27); MCM2 (phospho S27); p-MCM2 (phospho S27); BM28; CCNL 1; CCNL1; CDC like 1; CDC like-1; cdc19; CDCL 1; CDCL1; Cell devision cycle like 1; Cyclin like 1; cyclin like-1; D3S3194; DNA replication licensing factor MCM2; KIAA0030; MCM 2; MCM2; MCM2 minichromosome maintenance deficient 2 mitotin; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae); MCM2 minichromosome maintenance deficient 2, mitotin; MCM2_HUMAN; MCM2_MOUSE; MGC10606; Minichromosome maintenance complex component 2; Minichromosome maintenance deficient 2 (mitotin); Minichromosome maintenance deficient 2 mitotin; Minichromosome maintenance protein 2; Minichromosome maintenance protein 2 homolog; Mitotin; Nuclear protein BM28; OTTHUMP00000216047; OTTHUMP00000216050.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 細胞生物  免疫學  染色質(zhì)和核信號  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Dog, Pig, Rabbit, )
產(chǎn)品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 101kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 phosphopeptide derived from human MCM2 around the phosphorylation site of Ser27
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]

Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.

Subunit:
Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5. Interacts with KAT7 and DBF4. May interact with MCM10. Subcellular Location : Nucleus (Probable).

Subcellular Location:
Cytoplasm. Nucleus. Isoform LIMK2a is distributed in the cytoplasm and the nucleus and Cytoplasm. Nucleus. Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.

Post-translational modifications:
Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. Phosphorylation by the CDC7-DBF4 complex during G1/S phase is required for the initiation of DNA replication.

Similarity:
Belongs to the MCM family. Contains 1 MCM domain.

Database links:

Entrez Gene: 4171 Human

Entrez Gene: 17216 Mouse

Entrez Gene: 312538 Rat

Omim: 116945 Human

SwissProt: P49736 Human

SwissProt: P97310 Mouse

Unigene: 477481 Human

Unigene: 16711 Mouse

Unigene: 2715 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
久久久久久免费一区二区三区 | 在线视频精品免费观看10 | AV无码播放一级毛片免费野外 | 九九久久精品国产免费看小说 | 亚洲AV色香蕉一区二区三区 | 欧美最猛黑人XXXXWWW | 少妇被躁爽到高潮无码麻豆AV | 久久99蜜桃精品久久久久 | 永久免费A片在线观看无码 免费一级A片毛毛片在线播放99 | 亚洲国产系列一区二区三区 | 男人靠女人的免费视频 | 日韩一区二区三区四区区区 | 一级毛片正片免费视频手机看 | 中文字幕人妻偷人伦在线视频 | 日韩精品免费一区二区 | 综合欧美亚洲首页在线播放 | 久久91亚洲精品中文字幕 | 国产又爽又黄又不遮挡视频 | 狠狠综合久久AV一区二区三区 | WWW国产精品内射老师 | 18禁美女裸体网站免费扒内衣 | 日韩一区二无码专区播放 | 在线点播亚洲日韩国产欧美 | 国产AV电影区二区三区曰曰骚网 | 亚洲欧美日韩在线不卡 | 日日噜噜夜夜狠狠久久丁香五月 | 欧美mv日韩mv国产mv网站 | 农村女人一级毛片20岁的毛片 | 一级内射片在线网站观看 | 欧美一级高清AAA片免费观看 | 91偷伦一区二区三区蜜臀 | 精品无码国产AV一区二区性色 | 艳妇臀荡乳欲伦69调教视频 | 国产成人综合久久精品免费欧美91 | 亚洲精品123区在线观看 | 51吃瓜中心-吃最新最真的瓜 | 黄色a级免费网站 | 久久精品中文骚妇内射 | 成人国产欧美大片一区 | 久久se精品一区精品二区 | 曰韩一级a片欧美一级a片 |