亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
精品国产午夜福利在线观看,免费国产成人高清在线视频
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-NFIP1/PE-Cy5.5 Conjugated antibody (bs-19058R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-19058R-PE-Cy5.5
英文名稱 Rabbit Anti-NFIP1/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的乳腺癌相關蛋白SGA 1M抗體
別    名 0610010M22Rik; Breast cancer associated protein SGA 1M; Breast cancer-associated protein SGA-1M; MGC10924; N4WBP5; Ndfip1; Nedd4 family interacting protein 1; NEDD4 family-interacting protein 1; NEDD4 WW domain binding protein 5; NEDD4 WW domain-binding protein 5; NFIP1_HUMAN; Putative MAPK activating protein PM13; Putative MAPK-activating protein PM13; Putative NF kappa B activating protein 164; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK activating protein; Putative NFKB and MAPK-activating protein.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NFIP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]

Function:
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.

Subunit:
Forms heterodimers with NDFIP2. Interacts with several E3 ubiquitin-protein ligases, including NEDD4, NEDD4L and WWP2. Interacts with ITCH, U2SURP and WWP2 By similarity. The interaction with NEDD4, NEDD4L and ITCH leads to relocalization of these proteins to exosomes and eventually to exosomal secretion. Interacts with SLC11A2/DMT1. Interacts with PTEN. May interact with phosphorylated EGFR.

Subcellular Location:
Endosome membrane. Golgi apparatus membrane. Secreted. Detected in exosomes and secreted via the exosomal pathway.

Tissue Specificity:
Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.

Post-translational modifications:
Ubiquitinated by NEDD4 and ITCH; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its degradation.
Undergoes transient tyrosine phosphorylation following EGF stimulation, most probably by catalyzed by SRC. Phosphorylation SRC is enhanced in the presence of NDFIP2 which may act as a scaffold to recruit SRC to NDFIP1.

Database links:

Entrez Gene: 80762 Human

Entrez Gene: 65113 Mouse

Entrez Gene: 291609 Rat

Omim: 612050 Human

SwissProt: Q9BT67 Human

SwissProt: Q8R0W6 Mouse

SwissProt: Q5U2S1 Rat

Unigene: 653510 Human

Unigene: 9788 Human

Unigene: 102496 Mouse

Unigene: 59254 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚洲一本到无码aV中文字幕 | YELLOW免费观看完整版直播 | 欧美又黄又粗又大AV毛 | 在线观看黄网视频免费播放 | 欧美肥妇bbwbbwxx | 九九久久精品国产免费看小说 | 欧美巨鞭大战丰满少妇 | A级成人毛片免费视频 | 全黄H全肉短篇禁乱NP慕浅浅 | 性欧美大战久久久久久久黑人 | 国内久久久久久久久久 | 国产猛男猛女超爽免费视频 | 毛片无码免费无码播放 | 精品无码一区二区三区不卡 | 公办室系办系奷系奷系 | 久久精品免费视频观看 | 亚洲欧洲中文日韩AV无码 | 日本产品和韩国产品哪个好99 | 中文字日产幕码三区的做法大全 | 国产亚洲福利精品一区 | 91久久综合精品国产丝袜长腿 | 久久久91精品国产一区二区 | 欧美日韩激情无码专区 | 曰韩一级a片欧美一级a片 | 美女又大又黄www免费网站 | 国精品无码人妻一区二区三区 | 一本久久a久久精品免费不卡 | 国产成a人亚洲精v品久久网 | 肉到痉挛中出痴汉在线播放 | 国产一区二区无码蜜芽精品 | 伊人99综合精品视频 | 国产亚洲精品无码专区不卡 | 色偷偷噜噜噜亚洲男人 | 精品国产乱码久久久久久毛片 | 免费在线观看成人电影 | 日韩美女做暖暖免费视频 | 久久婷婷五月国产色综合 | 999国内精品永久免费视频 | 久久国内免费视频 | 一级卡片亚洲精品发布 | 国产精品亚洲综合五月天 |