亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产乱码精品一品二品,精品欧美一区二区三区久久久
Rabbit Anti-NDFIP2/PE-Cy5.5 Conjugated antibody (bs-19059R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-19059R-PE-Cy5.5
英文名稱 Rabbit Anti-NDFIP2/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的NDFIP2抗體
別    名 Ndfip2; NEDD4 family interacting protein 2; NEDD4 family-interacting protein 2; NEDD4 WW domain binding protein 5A; NEDD4 WW domain-binding protein 5A; NFIP2_HUMAN; Putative MAPK activating protein PM04/PM05/PM06/PM07; Putative MAPK-activating protein PM04/PM05/PM06/PM07; Putative NF kappa B activating protein 413; Putative NF-kappa-B-activating protein 413.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NDFIP2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 ∑C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20∑C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ∑C.
產(chǎn)品介紹 background:
NDFIP2 is a 336 amino acid protein that localizes to the membrane of both the endosome and the golgi apparatus. Expressed in kidney, heart, brain, lung, liver, placenta and skeletal muscle, Ndfip2 interacts with NEDD4 and NEDD4-L and is thought to be involved in endocytosis and in the NFⅹB and MAPK signaling pathways. Additionally, Ndfip2 may function as an adaptor protein that may recruit NEDD4 ubiquitin-protein ligases to protein trafficking machinery in the golgi. Ndfip2 is activated by T cells and may be ubiquitinated by NEDD4 or NEDD4-L, an event that does not affect Ndfip2 function. The gene encoding Ndfip2 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.

Function:
Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling.

Subunit:
Forms heterodimers with NDFIP1. Interacts with HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4. Interacts with NEDD4L By similarity. Interacts with PTEN. When phosphorylated at Tyr-167, interacts with SRC and LYN SH2 domain. May thus act as a scaffold that recruits SRC to NDFIP1, enhancing NDFIP1 phosphorylation. Interacts with SLC11A2/DMT1. May interact with phosphorylated EGFR.

Subcellular Location:
Endosome membrane. Golgi apparatus membrane. Endosome > multivesicular body membrane.

Tissue Specificity:
Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta.

Post-translational modifications:
Ubiquitinated by NEDD4 and ITCH. Also ubiquitinated by NEDD4L. Ubiquitination by NEDD4 or NEDD4L does not affect turnover.
Undergoes transient tyrosine-phosphorylation following EGF stimulation, most probably catalyzed by SRC. Also phosphorylated by LYN and FYN.

Database links:

Entrez Gene: 76273 Mouse

Entrez Gene: 361089 Rat

SwissProt: Q91ZP6 Mouse

SwissProt: F1M5D2 Rat

Unigene: 290669 Mouse

Unigene: 387487 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
在线视频一区二区三区不卡 | 成年网站免费人性视频a站 老司机在线精品视频网站 亚洲色熟女图激情另类图区 | a级全黄试频试看30分钟 | 最近的2019中文字幕国语HD | 特黄特色欧美亚洲高清二区 | 亚洲成年人免费网站 | 久久久这里只有精品加勒比 | 亚洲国产欧美日韩成人综合 | miaa213永濑唯在线观看 | 国产免费看又黄又大又污的胸 | 成人片在线观看地址KK4444 | 国偷自产一区二区免费 | 91麻精品国产91久久久久 | 啊…嗯啊好深男男腐文多人 | 97亚洲熟妇自偷自拍另类图片 | 日韩欧美高清一区 | 在线视频这里只有精品 | 粉嫩被两个粗黑疯狂进出 | 国产精品免费久久久久影院 | 久久免费精品高清麻豆 | 亚洲精品卡2卡3卡4卡5卡区 | 久久99精品久久久久久 | 一区二区三区精品视频 | 久久只这里是精品66 | 久久99精品久久久久久清纯直播 | WBBBB搡BBBB搡BBBB 美女性爽视频国产免费 | WWW夜片内射视频在观看视频 | 国产精品视频全国免费观看 | 亚洲欧洲日韩国产一区二区三区 | 美女裸免费观看网站 | 717影院理论午夜伦八戒 | 精品一区二区三区高清免费观看 | 日韩精品福利视频一区二区三区 | 国产日产欧产精品精品 | 亚洲无线码在线一区观看 | 国产毛片女人高潮叫声 | 免费无码又爽又黄又刺激网站 | 涩里番app黄版网站 无限资源免费观看视频大全 | 欧美老熟妇又粗又大 | 黑白配黑粗硬大疯狂乱叫 | 国产精品久久久久三级无码 |