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Rabbit Anti-NDC1/Gold Conjugated antibody (bs-19057R-Gold)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-19057R-Gold
英文名稱 Rabbit Anti-NDC1/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的跨膜蛋白48
別    名 nucleoporin NDC1; TMEM48; transmembrane protein 48; NET3.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  染色質(zhì)和核信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Cat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 75kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NDC1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
NDC1 is a 674 amino acid multi-pass membrane protein, central core structure of the nuclear pore complex (NPC) and member of the NDC1 family that is crucial for selective nuclear protein import. Existing as four alternatively spliced isoforms that are encoded by a gene located on human chromosome 1, NDC1 interacts with Nup35 and anchors Aladin to the nuclear envelope of the NPC, a region of macromolecular transport between the nucleus and cytoplasm. In the absence of NDC1, Aladin becomes mislocalized and may lead to the development of an autosomal recessive disorder termed achalasia-addisonianism-alacrima (triple A) syndrome. Triple A syndrome is characterized by achalasia, alacrima and adrenocortico-tropin-resistant adrenal insufficiency. Robust expression in neural systems associated with cognitive, motor and sensory functions is consistent with the myriad of symptoms experienced by patients with triple A syndrome.

Function:
Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.

Subunit:
Interacts with the NUP35/NUP53 By similarity. Interacts with AAAS, anchoring it to the nuclear envelope.

Subcellular Location:
Nucleus; nuclear pore complex; multipass membrane protein

Similarity:
Belongs to the NDC1 family.

Database links:

Entrez Gene: 55706 Human

Entrez Gene: 72787 Mouse

Entrez Gene: 362557 Rat

Entrez Gene: 335236 Zebrafish

Omim: 610115 Human

SwissProt: Q9BTX1 Human

SwissProt: Q8VCB1 Mouse

SwissProt: Q6AXN4 Rat

SwissProt: Q7SZC5 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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