亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
娇喘嗯嗯~轻点啊视频福利 ,久久久久国产精品喷潮免费观看臀 ,国偷自产一区二区免费
Rabbit Anti-DCP1A/RBITC Conjugated antibody (bs-10788R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-10788R-RBITC
英文名稱 Rabbit Anti-DCP1A/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的脫帽酶1A抗體
別    名 DCP1 decapping enzyme homolog A; Dcp1a; DCP1A_HUMAN; mRNA decapping enzyme 1A; mRNA-decapping enzyme 1A; Smad4 interacting transcriptional co activator; Smad4-interacting transcriptional co-activator; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIF; Transcription factor SMIF.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 染色質(zhì)和核信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DCP1A
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Cleavage of the 5'-cap structure is involved in the major 5'-to-3' and nonsense-mediated mRNA decay pathways. The protein complex consisting of Dcp1 and Dcp2 has been identified as the species responsible for the decapping reaction in Saccharomyces cerevisiae. In nonsense-mediated decay, the human decapping complex, made up of S. cerevisiae homologs hDcp1a and hDcp2, may be recruited to mRNAs containing premature termination codons by nonsense-mediated decay factor (Upf) proteins. hDcp2 specifically hydrolyzes methylated capped RNA to release m(7)GDP, thereby aiding in mRNA degradation. Both hDcp1a and hDcp2 colocalize in the cytoplasm. In addition, hDcp1a interacts with Smad4 forming a complex with TGF Beta and BMP-4. hDcp1a and Smad4 interact directly through a EVH1/WH1 domain on hDcp1a and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of hDcp1a as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of hDcp1a eliminates TGF Beta-induced nuclear translocation of hDcp1a.

Function:
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

Subunit:
Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Binds DCP1B, UPF1 and SMAD4. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with PNRC2. Interacts with DDX17 in an RNA-independent manner. Interacts with ZC3HAV1.

Subcellular Location:
Cytoplasm, P-body. Nucleus. Co-localizes with NANOS3 in the processing bodies. Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4.

Tissue Specificity:
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.

Similarity:
Belongs to the DCP1 family.

Database links:

Entrez Gene: 55802 Human

Entrez Gene: 75901 Mouse

Entrez Gene: 361109 Rat

Omim: 607010 Human

SwissProt: Q9NPI6 Human

SwissProt: Q91YD3 Mouse

Unigene: 476353 Human

Unigene: 28733 Mouse

Unigene: 206852 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
一本AV高清一区二区三区 | 娇妻在客厅被朋友玩得呻吟漫画 | 欧美日韩精品久久久免费观看 | 怡红院日本一道日本久久 | 韩国免费一级a一片在线播放 | 国产精品一区二区三区免费 | 国产福利影院在线观看 | 国产三级在线观看视频 | 中文字幕高清在线免费播放 | 久久久久久久国产视频 | 成人免费看AA片 | 国产精品一区二区不卡的视频 | 亚洲精品无码天堂AV | 久久久久久久精品国产亚洲蜜臀 | 日本那些又骚又爽的视频 | 日韩福利视频精品专区 | 两根硕大一起挤进小紧H共妻 | 亚欧洲乱码视频一二三区 | 亚州AV一级特黄大片 | 久久久久久久久久久免费精品国产 | 国产精品一区二区熟女不卡 | 久久婷婷五月国产色综合 | 国产超碰人人模人人爽人人添 | 国产后进白嫩翘臀在线动漫 | 国产一级毛片国产 | 亚洲AV一宅男色影视 | 黄网站在线观看高清免费 | 欧美激情一区二区三区蜜桃视频 | 嫩BBB槡BBBB搡BBBB | 欧美mv日韩mv国产mv | 亚洲人午夜射精精品日韩 | 国产91在线精品国自产在线 | 欧美性爱视频在线播放 | 99国产精品一区二区三区四区五区 | 最新中文字幕A片专区 | 高清少妇熟女一区二区 | 欧美XXXXX高潮喷水麻豆 | 直接看的av网址免费的 | 91日本在线观看亚洲精品 | 九色91精品国产网站 | 欧美.日韩.日本国产视频 |