亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
狠狠色色综合网站,女人被狂躁C到高潮,成人满18在线观看网站免费
Rabbit Anti-Phospho-Jak3 (Tyr785)/Gold Conjugated antibody (bs-20168R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-20168R-Gold
英文名稱 Rabbit Anti-Phospho-Jak3 (Tyr785)/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的磷酸化蛋白酪氨酸激酶JAK-3抗體
別    名 JAK3 (phospho Y785); p-JAK3 (phospho Y785); EC 2.7.10.2; JAK 3; JAK L; JAK-3; Jak3; JAK3 HUMAN; JAK3_HUMAN; JAKL; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus kinase 3; Janus Kinase3; L JAK; L-JAK; Leukocyte janus kinase; LJAK; Protein tyrosine kinase leukocyte; Tyrosine protein kinase JAK3; Tyrosine-protein kinase JAK3.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  免疫學(xué)  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 125kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Phospho-Jak3 (Tyr785)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]

Function:
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

Subunit:
Interacts with STAM2 and MYO18A. Interacts with SHB.

Subcellular Location:
Endomembrane system; Peripheral membrane protein. Cytoplasm.

Tissue Specificity:
In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.

Post-translational modifications:
Tyrosine phosphorylated in response to IL-2 and IL-4.

DISEASE:
Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T(-)B(+)NK(-) SCID) [MIM:600802]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 2 protein kinase domains.
Contains 1 SH2 domain.

Database links:

Entrez Gene: 3718 Human

Entrez Gene: 16453 Mouse

Omim: 600173 Human

SwissProt: P52333 Human

SwissProt: Q62137 Mouse

Unigene: 515247 Human

Unigene: 249645 Mouse

Unigene: 476857 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产乱码精品一品二品 | 最近最新精品欧美日本韩亚洲中文国产 | 99国产欧美久久久精品 | 免费被黄动漫网站在线无网观看 | 国产成人精品18 | 久青青在线观看视频国产 | 国产一级无码免费不卡| 国产综合色产在线精品 | 真实亲子乱一区二区三区 | 久久线看在观草草青青脱裤 | 豪妇荡乳1一5白玉兰免费下载 | 国产精品美女www爽爽爽视频 | 欧美人与性囗牲恔配视频0 国产成人精品久久一区二区三区 | 亚洲精品无码久久毛片 | 五月天婷五月天综合网 | 日本又黄又爽又色又刺激的视频 | 人妻中文字幕乱人伦在线 | 国产精品毛片一级久久 | 免费大片av手机看片 | 久久久无码人妻精品无码 | 国产美女一级视频 | 成人片黄网站色大片免费 | 超清无码A片在线观看不卡 大乳妇女BD丰满 | 免费晚上看片www | 久久久无码精品一区二区三区 | 欧洲妓女在线视频免费看 | a毛片在线看免费观看 | 日韩精品免费在线观看 | 亚洲国产精品成人AV无码久久综合网 | 国产又滑又嫩又白 | 又污又黄又无遮挡的网站国产 | 欧美性猛交黑人粗大 | 久久人人爽人人爽人人片AV浪潮 | 色欲精品久久人妻av中文字幕 | 久久综合视频网站 | 97人人超碰国产精品最新 | 搡BBB搡BBBB搡BBBB | 蜜臀色欲AV在线播放国产日韩 | 日本中文字幕有码在线视频 | 老师好大乳好紧好深动态图 | 野花视频在线观看高清免费完整版 |