亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
午夜熟女插插XX免费视频,色欲狠狠躁天天躁无码中文字幕
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-Jak3 (Tyr785)/Cy7 Conjugated antibody (bs-20168R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-20168R-Cy7
英文名稱 Rabbit Anti-Phospho-Jak3 (Tyr785)/Cy7 Conjugated antibody
中文名稱 Cy7標記的磷酸化蛋白酪氨酸激酶JAK-3抗體
別    名 JAK3 (phospho Y785); p-JAK3 (phospho Y785); EC 2.7.10.2; JAK 3; JAK L; JAK-3; Jak3; JAK3 HUMAN; JAK3_HUMAN; JAKL; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus kinase 3; Janus Kinase3; L JAK; L-JAK; Leukocyte janus kinase; LJAK; Protein tyrosine kinase leukocyte; Tyrosine protein kinase JAK3; Tyrosine-protein kinase JAK3.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  染色質和核信號  信號轉導  轉錄調節(jié)因子  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 125kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Phospho-Jak3 (Tyr785)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]

Function:
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

Subunit:
Interacts with STAM2 and MYO18A. Interacts with SHB.

Subcellular Location:
Endomembrane system; Peripheral membrane protein. Cytoplasm.

Tissue Specificity:
In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.

Post-translational modifications:
Tyrosine phosphorylated in response to IL-2 and IL-4.

DISEASE:
Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T(-)B(+)NK(-) SCID) [MIM:600802]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 2 protein kinase domains.
Contains 1 SH2 domain.

Database links:

Entrez Gene: 3718 Human

Entrez Gene: 16453 Mouse

Omim: 600173 Human

SwissProt: P52333 Human

SwissProt: Q62137 Mouse

Unigene: 515247 Human

Unigene: 249645 Mouse

Unigene: 476857 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
久久久久久久久性潮 | 老师好大好深好烫撑满了h 亚洲精品综合第一国产综合 | A级无遮挡超级高清-在线观看 | 在线观看亚洲AV无码每日更新 | 久久国产精品免费网站 | 亚洲中文久久精品中文字幕 | 久久精品国产精品亚洲色婷婷 | 国产精品99精品无码视亚 | WWW射我里面在线观看 | 欧美日韩中文字幕群交视频在线观看 | 嫦娥仙子含精肉臀迎合 | 性欧美video另类hd亚洲人 | 青青青免费高清在线观看一区二区 | 国产手机在线国内精品 | 亚洲AV无码国产精品久久久不卡 | 国产午夜精品一区二区三区软件 | 亚洲欧洲日韩国产一区二区三区 | 国产精品无码久久久最线观看 | 9九色桋品熟女内射 | 亚洲日本香蕉视频观看视频 | 亚州**色毛片免费观看 | 性欧美18处19处破在线观看 | 国产精品国产三级国产AV麻豆 | 国产欧美一区二区精品性色超碰 | 成人高清视频在线观看大全 | 久久综合色一综合色88 | 欧美35页视频在线观看 | 久久强奷乱码老熟女网站 | 少妇被躁爽到高潮无码人狍大战 | 久久精品99国产精品日本 | 国产精品污WWW在线观看 | 日本中文字幕在线免费观看一区二区 | 羞羞漫画美女裸体无遮挡 | 欧美牲交A欧美牲交VDO | 影音先锋女人AA鲁色资源 | 美女裸体动态图片 | 三上悠亚激情AV一区二区三区 | 无码人妻啪啪一区二区 | 亚洲和欧洲一码二码区别7777 | 一级毛片视频免费观看 | 男女无遮挡XX00动态图120秒 |