亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国模沟沟一区二区三区,日日噜噜噜夜夜爽爽狠狠,最近中文免费字幕无吗
Rabbit Anti-Phospho-Jak3 (Tyr785)/PE-Cy3 Conjugated antibody (bs-20168R-PE-Cy3)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-20168R-PE-Cy3
英文名稱 Rabbit Anti-Phospho-Jak3 (Tyr785)/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的磷酸化蛋白酪氨酸激酶JAK-3抗體
別    名 JAK3 (phospho Y785); p-JAK3 (phospho Y785); EC 2.7.10.2; JAK 3; JAK L; JAK-3; Jak3; JAK3 HUMAN; JAK3_HUMAN; JAKL; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus kinase 3; Janus Kinase3; L JAK; L-JAK; Leukocyte janus kinase; LJAK; Protein tyrosine kinase leukocyte; Tyrosine protein kinase JAK3; Tyrosine-protein kinase JAK3.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 125kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Phospho-Jak3 (Tyr785)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]

Function:
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

Subunit:
Interacts with STAM2 and MYO18A. Interacts with SHB.

Subcellular Location:
Endomembrane system; Peripheral membrane protein. Cytoplasm.

Tissue Specificity:
In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.

Post-translational modifications:
Tyrosine phosphorylated in response to IL-2 and IL-4.

DISEASE:
Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T(-)B(+)NK(-) SCID) [MIM:600802]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 2 protein kinase domains.
Contains 1 SH2 domain.

Database links:

Entrez Gene: 3718 Human

Entrez Gene: 16453 Mouse

Omim: 600173 Human

SwissProt: P52333 Human

SwissProt: Q62137 Mouse

Unigene: 515247 Human

Unigene: 249645 Mouse

Unigene: 476857 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
麻豆一区二区免费播放网站 | 免费一区二区三区久久 | 国产亚洲精品香蕉视频 | 人妻仑乱少妇88MAV | 免费国产成人高清在线网站东京 | 午夜福利一区二区三区在线观看 | 精产国品一区二区三产区 | 一级毛片在线免费播放 | 无码狠狠躁久久久久久久 | 裸露双乳挤奶无遮掩裸体私房视频 | 亚洲天天网综合自拍图片专区 | 高清少妇熟女一区二区 | 午夜熟女插插XX免费视频 | 无码精品人妻一区二区三区涩爱 | 国产亚洲精品女人久久久久久 | 一级毛片在线免费视频 | 亚洲AV无码乱码国产麻豆穿越 | 夜夜爱成人免费网站 | 国产精品久久国产三级国电话系列 | 久久se精品一区精品二区 | 无码AV免费精品一区二区三区 | 日韩一区二区三区四区区区 | 无码区国产区在线播放 | 国产人妖XXXX做受视频 | 日韩欧美视频一区二区 | 一本一本久久a久久精品66 | 人人看人人摸人人操637 | 99久久精品费精品国产一区二区 | 宝贝别忍着喷出来嗯啊哦漫画 | 国产高颜值大学生情侣酒店 | 妖精视频一区二区免费 | 亚洲色大成网站WWW永久 | 人妻无码专区一专区二专区三 | 国内大量揄拍人妻精品视频 | 欧美一级a人与一级A片在线观看 | 天堂资源在线官网bt | 91精品国产色综合久久不卡美美 | 一区二区三区国产 | 日韩久久久久久无码精品 | 久99视频精品免费观看福利 | 久久婷婷五月国产色综合 |