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Rabbit Anti-Neogenin/APC Conjugated antibody (bs-20422R-APC)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-20422R-APC
英文名稱(chēng) Rabbit Anti-Neogenin/APC Conjugated antibody
中文名稱(chēng) APC標(biāo)記的神經(jīng)細(xì)胞粘附蛋白NGN抗體
別    名 NGN; Neo1; Neo 1; Neogenin; NEO1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞粘附分子  細(xì)胞分化  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 156kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Neogenin
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a cell surface protein that is a memberof the immunoglobulin superfamily. The encoded protein consists offour N-terminal immunoglobulin-like domains, six fibronectin typeIII domains, a transmembrane domain and a C-terminal internaldomain that shares homology with the tumor suppressor candidategene DCC. This protein may be involved in cell growth anddifferentiation and in cell-cell adhesion. Defects in this gene areassociated with cell proliferation in certain cancers. Alternatesplicing results in multiple transcript variants. [provided byRefSeq, Feb 2010].

Function:
Neogenin is one of several netrin-binding proteins. Neogenin functions as an Repulsive Guidance Molecule (RGM) receptor; RGM is implicated in axonal guidance and neural tube closure.

Subunit:
Interacts with RGMA. Interacts with MYO10

Subcellular Location:
Cell membrane; Single-pass type I membraneprotein.

Tissue Specificity:
Widely expressed and also in cancer celllines.

Similarity:
Belongs to the immunoglobulin superfamily. DCC family.
Contains 6 fibronectin type-III domains.
Contains 4 Ig-like C2-type (immunoglobulin-like)domains.

Database links:

Entrez Gene: 4756 Human

Entrez Gene: 18007 Mouse

Entrez Gene: 81735 Rat

Omim: 601907 Human

SwissProt: Q92859 Human

SwissProt: P97798 Mouse

SwissProt: P97603 Rat

Unigene: 388613 Human

Unigene: 42249 Mouse

Unigene: 10667 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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