亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产精品视频26uuu,国产又滑又嫩又白,草草在线观看视频
Rabbit Anti-phospho-DNA PKcs (Ser2056)/Cy7 Conjugated antibody (bs-20069R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-20069R-Cy7
英文名稱 Rabbit Anti-phospho-DNA PKcs (Ser2056)/Cy7 Conjugated antibody
中文名稱 Cy7標(biāo)記的磷酸化DNA依賴性蛋白激酶抗體
別    名 DNA PK (phospho S2056); p-DNA PK (phospho S2056); PRKDC (phospho T2056); phospho-DNA PKcs (Ser4097)(isoform 2); DNA PKcs (phospho-Ser4097)(isoform 2); DNA PKcs (phospho S4097)(isoform 2); DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNA PKcs; DNPK1; p460; PRKDC; HYRC; HYRC1; Variant; DNAPK; DNAPK catalytic subunit; p350; PRKDC; Protein Kinase DNA Activated Catalytic Polypeptide; XRCC 7; XRCC7; PRKDC_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細胞生物  免疫學(xué)  染色質(zhì)和核信號  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Horse, Rabbit, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 454kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human phospho-DNA PKcs (Ser2056)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]

Function:
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D.

Subunit:
DNA-PK is a heterotrimer of PRKDC and the Ku p70-p86 (XRCC6-XRCC5) dimer. Formation of this complex may be promoted by interaction with ILF3. Associates with the DNA-bound Ku heterodimer, but it can also bind to and be activated by free DNA. Interacts with DNA-PKcs-interacting protein (KIP) with the region upstream the kinase domain. PRKDC alone also interacts with and phosphorylates DCLRE1C, thereby activating the latent endonuclease activity of this protein. Interacts with C1D. Interacts with TTI1 and TELO2.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. Autophosphorylated on Thr-2609, Thr-2638 and Thr-2647. Thr-2609 is a DNA damage-inducible phosphorylation site (inducible with ionizing radiation, IR). Autophosphorylation induces a conformational change that leads to remodeling of the DNA-PK complex, requisite for efficient end processing and DNA repair.
S-nitrosylated by GAPDH.

Similarity:
Belongs to the PI3/PI4-kinase family.
Contains 1 FAT domain.
Contains 1 FATC domain.
Contains 2 HEAT repeats.
Contains 1 PI3K/PI4K domain.
Contains 3 TPR repeats.

Database links:

Entrez Gene: 5591 Human

Entrez Gene: 19090 Mouse

Entrez Gene: 360748 Rat

Omim: 600899 Human

SwissProt: P78527 Human

SwissProt: P97313 Mouse

Unigene: 491682 Human

Unigene: 71 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
爱剪辑视频社区在线资源 | 欧美日韩人妻精品一区在线 | 欧美国产综合日韩一区二区 | 日本国产一区二区三区 | 久久久久久精品免费自慰 | 肉大捧一进一出免费视频 | 女人被男人吃奶到高潮 | 国产精品老熟女视频一区二区 | 亚洲色欲AV无码成人专区 | 免费在线视频一区 | 欧美性大战xxxxx久久久 | 免费一级毛片在线观看 | 午夜av内射一区二区三区红桃视 | 欧美三级在线免费观看 | 日韩三级中文字幕 | 大片免免费观看视频播放网站 | 国产精品老师色诱在线 | 狼人大香伊蕉国产WWW亚洲 | 国产精品精品久久久久久 | 高清无码视频在线观看 | 丰满老女人一级毛片视频 | 精品国产青草久久久久福利 | 高清少妇熟女一区二区 | 绿意盎然侄子小钢炮的成长经历 | 亚洲中文乱码AV网站 | 人妻体内射精一区二区 | 日本高清视频一区二区 | 久色乳综合思思在线视频 | AV无码免费一区二区三区不卡 | 中文字幕人妻紧无码专区 | 最新国产精品好看的国产精品 | 国内精品51视频在线观看 | 精品蜜臀AV在线天堂 | 24小时日本免费观看高清视频 | 亚洲欧洲日韩国产一区二区三区 | 成年轻人网站免费视频 | 国产一区二区三区AV天堂 | 亚洲AV无码国产精品久久久不卡 | 好紧好爽好疼的免费视频全集完整版在线播放 | 高清有码国产一区二区 | 无码AV熟妇素人内射V在线 |