亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
搡BBBB搡BBBB搡BBBB,亚洲一区二区视频在线观看
Rabbit Anti-phospho-DNA PKcs (Ser2056)/BF488 Conjugated antibody (bs-20069R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-20069R-BF488
英文名稱 Rabbit Anti-phospho-DNA PKcs (Ser2056)/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的磷酸化DNA依賴性蛋白激酶抗體
別    名 DNA PK (phospho S2056); p-DNA PK (phospho S2056); PRKDC (phospho T2056); phospho-DNA PKcs (Ser4097)(isoform 2); DNA PKcs (phospho-Ser4097)(isoform 2); DNA PKcs (phospho S4097)(isoform 2); DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNA PKcs; DNPK1; p460; PRKDC; HYRC; HYRC1; Variant; DNAPK; DNAPK catalytic subunit; p350; PRKDC; Protein Kinase DNA Activated Catalytic Polypeptide; XRCC 7; XRCC7; PRKDC_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Horse, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 454kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human phospho-DNA PKcs (Ser2056)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]

Function:
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D.

Subunit:
DNA-PK is a heterotrimer of PRKDC and the Ku p70-p86 (XRCC6-XRCC5) dimer. Formation of this complex may be promoted by interaction with ILF3. Associates with the DNA-bound Ku heterodimer, but it can also bind to and be activated by free DNA. Interacts with DNA-PKcs-interacting protein (KIP) with the region upstream the kinase domain. PRKDC alone also interacts with and phosphorylates DCLRE1C, thereby activating the latent endonuclease activity of this protein. Interacts with C1D. Interacts with TTI1 and TELO2.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. Autophosphorylated on Thr-2609, Thr-2638 and Thr-2647. Thr-2609 is a DNA damage-inducible phosphorylation site (inducible with ionizing radiation, IR). Autophosphorylation induces a conformational change that leads to remodeling of the DNA-PK complex, requisite for efficient end processing and DNA repair.
S-nitrosylated by GAPDH.

Similarity:
Belongs to the PI3/PI4-kinase family.
Contains 1 FAT domain.
Contains 1 FATC domain.
Contains 2 HEAT repeats.
Contains 1 PI3K/PI4K domain.
Contains 3 TPR repeats.

Database links:

Entrez Gene: 5591 Human

Entrez Gene: 19090 Mouse

Entrez Gene: 360748 Rat

Omim: 600899 Human

SwissProt: P78527 Human

SwissProt: P97313 Mouse

Unigene: 491682 Human

Unigene: 71 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
精品无码国产污污污在线观看 | 精品一卡2卡三卡4卡乱码毛1 | 久久久久国产精品夜夜夜夜夜 | 日韩高清一区二区三区不卡 | 国产高清av首播原创麻豆 | 欧洲妓女在线视频免费看 | 亚洲中文字幕无码视频 | 国产做a爱一级毛片久久 | 国产人成高清在线视频99 | 中文国产高清综合乱色视频在线播放 | 欧美一区二区视频在线观看 | onlyfans辛尤里福利视频 | 久久精品视频免费 | 久久强奷乱码老熟女网站 | 亚洲国产天堂99精品一区 | 91在线精品国产电影 | 国产高中生三级视频 | 熟女少妇一区二区三区 | 亚洲国产18成人中文字幕久久久久无码av | 欧美一级婬人妻欧美大片 | 亚洲国产精品高清免费在线观看 | 91国语精品自产拍在线观看性色 | 免费成人在线观看 | 日本在线电影一区二区三区 | 一区二区高清无码电影 | 印度一级特黄AAAAAA片在线看 | 一本久久a久久精品免费不卡 | 欧洲亚洲精品A片久久99果冻 | 国产娱乐凹凸视觉盛宴在线视频 | 亚洲一区精品在线 | 国产黄a一级二级三级看三区 | XXX2高清在线观看免费视频 | 亚洲第一区欧美国产不卡综合 | 亚洲国产精品一区二区三区在线观看 | 亚洲欧美国产精品专区久久综合高清 | 亚洲精品国产高清不卡在线 | 亚洲AV无码天堂2018 | 91热久久免费频精品黑人99 | 精品国产一区二区三区 | 91精品国产乱码久久无码 | 国产极品久久久久极品1000 |