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Rabbit Anti-RGS18/PE-Cy5.5 Conjugated antibody (bs-19858R-PE-Cy5.5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-19858R-PE-Cy5.5
英文名稱 Rabbit Anti-RGS18/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的G蛋白信號轉(zhuǎn)導(dǎo)調(diào)節(jié)因子18抗體
別    名 Regulator of G protein signalling 13; Regulator of G Protein Signalling 18; Regulator of G-protein signaling 18; RGS 18; RGS13; RGS18; RGS18_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RGS18
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver.

Similarity:
Contains 1 RGS domain.

Database links:

Entrez Gene: 64407 Human

Entrez Gene: 64214 Mouse

Entrez Gene: 289076 Rat

Omim: 607192 Human

SwissProt: Q9NS28 Human

SwissProt: Q99PG4 Mouse

SwissProt: Q4L0E8 Rat

Unigene: 440890 Human

Unigene: 253927 Mouse

Unigene: 202353 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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