亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
无码纯肉国产麻豆久久,亚洲精品蜜夜内射
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-PABP2/Cy5 Conjugated antibody (bs-19994R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-19994R-Cy5
英文名稱 Rabbit Anti-PABP2/Cy5 Conjugated antibody
中文名稱 Cy5標記的多聚腺苷酸結(jié)合蛋白2抗體
別    名 Nuclear poly(A) binding protein 1; PAB2; PABII; PABP2; PABPN1; Poly(A) binding protein 2; Polyadenylate binding nuclear protein 1; Polyadenylate binding protein 2; ROX2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  信號轉(zhuǎn)導(dǎo)  結(jié)合蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Dog, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PABP2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]

Function:
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).

Subunit:
May interact with SETX (PubMed:21700224). Monomer and homooligomer. Binds RNA as a monomer and oligomerizes when bound to poly(A). Interacts with PAPOLA, but only in presence of oligo(A) RNA. Interacts with transportin. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Association in a ternary complex with CPSF4 and influenza A virus NS1 blocks pre-mRNAs processing, thereby preventing nuclear export of host cell mRNAs. Associates in a single complex with SKIP and MYOD1 and interacts with SKIP in differentiated myocytes. Interacts with NUDT21/CPSF5.

Subcellular Location:
Cytoplasmic and Nuclear.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Arginine dimethylation is asymmetric and involves PRMT1 and PRMT3. It does not influence the RNA binding properties (By similarity).

DISEASE:
The disease is caused by mutations affecting the gene represented in this entry. Disease description:A form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.

Similarity:
Contains 1 RRM (RNA recognition motif) domain.

Database links:

Entrez Gene: 8106 Human

Entrez Gene: 18459 Mouse

Omim: 602279 Human

SwissProt: Q86U42 Human

SwissProt: Q8CCS6 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
精品国产乱码久久久久久浪潮 | 国产偷国产偷亚州清高APP | 国产成人无码AV麻豆 | 伊人久久大香线蕉AV超碰 | 久久久久精品国产亚洲av麻豆 | 五月的丁香六月的婷婷免费无毒不卡 | 大学生高潮无套内谢视频 | 人妻体内射精一区二区 | 国产精品网站在线观看免费传媒 | 国产成人无码区免费网站 | 亚洲精品无码a√中文字幕网站 | 久99久热只有精品国产女同 | 免费一级欧美大片视频APP | yy6080影院色呦呦私人 | 亚洲成人电影在线观看精品国产 | 久久精品中文字幕无码有码 | 色av综合av综合无码网站 | 日本高清VA在线播放 | 亚洲无线一二三四区手机 | 精品国产青草久久久久福利 | 少妇被又大又粗又爽毛片久久黑人 | 国产一级a毛一级a做免费图片 | 国产喷水1区2区3区咪咪爱AV | 亚洲熟女乱色一区二区三区 | 精产国品一区二区三产区 | 国产欧美p片内射在线 | 最近免费中文字幕大全免费版视频 | 天天躁日日躁狠狠躁日日躁黑人 | 91桃色无码国产在线观看二区 | 四虎影视永久免费观看 | 欧美透明丰满内衣内裤 | 亚洲v日韩v欧美v综合 | 国产又粗又猛又爽的视频国产 | 超清无码A片在线观看不卡 大乳妇女BD丰满 | 日本动态120秒免费 小宝极品内射国产在线 | 无码AV大香线蕉伊人久久九色 | 久久久久亚洲女同一区二区 | 日本在线电影一区二区三区 | 国产精品第1页在线观看 | 在线永久看片免费的视频 | 国产又黄又硬又粗 |