亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产日韩欧美一区二区东京热,久久99国产视频,一级毛片免费视频网站
Rabbit Anti-PABP2/PE-Cy3 Conjugated antibody (bs-19994R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-19994R-PE-Cy3
英文名稱 Rabbit Anti-PABP2/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的多聚腺苷酸結(jié)合蛋白2抗體
別    名 Nuclear poly(A) binding protein 1; PAB2; PABII; PABP2; PABPN1; Poly(A) binding protein 2; Polyadenylate binding nuclear protein 1; Polyadenylate binding protein 2; ROX2.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  結(jié)合蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Dog, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PABP2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]

Function:
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).

Subunit:
May interact with SETX (PubMed:21700224). Monomer and homooligomer. Binds RNA as a monomer and oligomerizes when bound to poly(A). Interacts with PAPOLA, but only in presence of oligo(A) RNA. Interacts with transportin. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Association in a ternary complex with CPSF4 and influenza A virus NS1 blocks pre-mRNAs processing, thereby preventing nuclear export of host cell mRNAs. Associates in a single complex with SKIP and MYOD1 and interacts with SKIP in differentiated myocytes. Interacts with NUDT21/CPSF5.

Subcellular Location:
Cytoplasmic and Nuclear.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Arginine dimethylation is asymmetric and involves PRMT1 and PRMT3. It does not influence the RNA binding properties (By similarity).

DISEASE:
The disease is caused by mutations affecting the gene represented in this entry. Disease description:A form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.

Similarity:
Contains 1 RRM (RNA recognition motif) domain.

Database links:

Entrez Gene: 8106 Human

Entrez Gene: 18459 Mouse

Omim: 602279 Human

SwissProt: Q86U42 Human

SwissProt: Q8CCS6 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
加勒比无码人妻一区二区三区 | 人妖欧美一区二区三区四区 | 国产精品无码不卡系列在线 | 免费无码无遮挡在线V视频 全黄裸片一29分钟免费真人版 | 亚洲免费在线播放 | 国产高清视频免费最新在线 | 精品久久久久久久一区二区 | 久久精品免费无码一级A片 亚洲精品123区 | 国产精品久久国产三级国电话系列 | 国色天香视频免费高清社区 | 国产女高清在线看免费观看 | 污污内射在线观看一区二区少妇 | 成人无遮挡免费网站视频在线观看 | 好好的曰com久久 | 国产午夜免费视频片夜色 | 97夜夜澡人人爽人人喊中国片 | 在线永久免费观看黄网站 | 欧美精品中文字幕亚洲专区 | 日本理伦片午夜理伦片 | 亚洲第一天堂WWW网站 | 亚洲精品永久在线观看 | 国产亚洲欧美日韩综合一区在线观看 | 爱爱好爽好大好紧视频 | 亚洲精品中文无码AV在线播放 | 美女内射无套日韩免费播放 | 国产三级在线免费 | 黄网站动漫免费永久在线观看网站入口 | 日韩精品在线观看免费 | 特黄特色欧美亚洲高清二区 | 又色又爽又黄又粗暴小说 | 久久久久久精品免费免费WE | 内射毛片内射国产夫妻 | www.一级片.com | 中文字幕人成人乱码亚洲电影 | 特级毛片内射WWW无码 | 调教我的妺妺H肉YIN荡视频 | 欧美日韩亚洲一区二区三区在线观看 | 抽插黄文NP合欢宗 | 无码视频在线肉在线播放美熟女 | 国产精品一区二区久久宅男宅女 | 日韩AV免费在线观看 |