亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美熟妇呻吟猛交XX性,亚洲无码无线在线观看,公交车掀开奶罩边躁狠狠躁视频
Rabbit Anti-SATB1/BF488 Conjugated antibody (bs-20148R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-20148R-BF488
英文名稱 Rabbit Anti-SATB1/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的核基質(zhì)結(jié)合區(qū)結(jié)合蛋白1抗體
別    名 DNA binding protein SATB1; DNA-binding protein SATB1; SATB homeobox 1; SATB1; SATB1_MOUSE; Special AT rich sequence binding protein 1 (binds to nuclear matrix/scaffold associating DNA); Special AT rich sequence binding protein 1; Special AT-rich sequence-binding protein 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 染色質(zhì)和核信號  結(jié)合蛋白  新陳代謝  線粒體  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SATB1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Function:
Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes.

Subunit:
Interacts with PCAF. Interacts with sumoylated PML and HDAC1 Tat via the PDZ-like dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300. Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts (via DNA-binding domains) with CUX1; leading to inhibit the attachment to DNA.

Subcellular Location:
Nucleus. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).

Tissue Specificity:
Mainly expressed in thymus, spleen, and lymph nodes with a lower level observed in the brain.

Post-translational modifications:
Sumoylated. Sumoylation promotes cleavage by caspases.
Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation.
Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms can not dimerize and lose transcription regulation function because of impaired DNA and chromatin association.

Similarity:
Belongs to the CUT homeobox family.
Contains 2 CUT DNA-binding domains.
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 6304 Human

Entrez Gene: 20230 Mouse

Omim: 602075 Human

SwissProt: Q01826 Human

SwissProt: Q60611 Mouse

Unigene: 517717 Human

Unigene: 311655 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产黑丝一区二区 | 男人的天堂精品国产一区 | 日本那些又骚又爽的视频 | 免费一级毛片不卡在线播放 | 捣烂宫口np失禁哭张开了h | 猛烈的抽插她丰满白嫩 | 好爽又高潮了毛片免费下载 | 為你提供福利吃瓜视频 | 99久热国产精品视频 | 国产精品路线1路线2路线 | 成年在线网站免费观看无广告 | 一二三区精品国产91久久久 | 成人午夜精品网站在线观看 | 2021年日本中文字幕在线 | 国产精品久久久久久精品毛片 | 亚洲乱码高清午夜理论电影 | 国产高清秘?成人久久 | 国产放荡AV剧情演绎麻豆 | 欧美精品偷拍一区二区 | 在线精品自偷自拍无码 | 狠狠躁日日躁夜夜躁2022麻豆 | 最近中文字幕完整版2018一页 | 成年女人毛片免费播放视频m | 成人午夜福利视频后入 | 999国内精品永久免费视频 | 美女性爽视频国产免费 | 狠狠躁夜夜躁人人爽天天69 | 久久久久久久久久国产精品免费 | 国产又黄又爽又猛免费app | 人妻人人澡人人爽人人精品 | 丰满爆乳肉感一区二区三区 | 0国产一级广片内射视频播放麻豆 | 无码精品A∨在线观看中文 欧美激情视频在线观看一区二区三区 | AV午夜午夜快憣免费观看 | 中文字幕日韩一区二区不卡 | 亚洲午夜福利在线视频 | 午夜AV内射一区二区三区红桃视 | 青青手机国产在线视频 | 国产女高清在线看免费观看 | 日本免费一级婬片A级中文字幕 | 肉到痉挛中出痴汉在线播放 |