亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
亚洲精品高清一二区久久 ,思思久久好好热精品国产,国产精品美女自在线观看免费
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-IRS1 (Tyr1179)/BF488 Conjugated antibody (bs-8709R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-8709R-BF488
英文名稱 Rabbit Anti-phospho-IRS1 (Tyr1179)/BF488 Conjugated antibody
中文名稱 BF488標記的磷酸化胰島素受體底物1抗體
別    名 IRS1 (phospho S1179); p-IRS1 (phospho S1179); p-IRS1; IRS1(phospho-Ser1179); HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS-1; IRS 1; IRS1; OTTHUMP00000164234; IRS1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  神經生物學  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, Danio rerio,)
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 132kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human IRS1 around the phosphorylation site of Ser1179.
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed. Function : May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Function:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Subunit:
Interacts with UBTF and PIK3CA. Interacts (via phosphorylated YXXM motifs) with PIK3R1. Interacts with ROCK1 and FER. Interacts (via PH domain) with PHIP. Interacts with GRB2. Interacts with SOCS7. Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif). Interacts with ALK.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.

Post-translational modifications:
Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding. Phosphorylated by ALK. Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1.

DISEASE:
Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].

Similarity:
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 3667 Human

Entrez Gene: 16367 Mouse

Entrez Gene: 25467 Rat

Omim: 147545 Human

SwissProt: P35568 Human

SwissProt: P35569 Mouse

SwissProt: P35570 Rat

Unigene: 471508 Human

Unigene: 4952 Mouse

Unigene: 10476 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
果冻传媒剧国产MV在线看 | 搡BBBB槡BBBB | 综合一区无套内射中文字幕 | 婷婷伊人久久大香线蕉AV | 国产高潮国产高潮久久久无码 | 久久久久久曰本av免费免费 | 日韩欧美一区二区三区免费看 | 久久er热在这里只有精品 | 国产无套内射普通话对白 | 高清国产激情视频在线观看 | 亚洲熟妇av一区二区三区色堂 | 欧美精品偷拍一区二区 | 99精品无码一区二区毛片免费 | 日韩欧美国产精品亚洲二区 | 国产无遮挡无码视频在线观看不卡 | 国产精品一区二区久久不卡 | 人妻少妇看AA片偷人精品视频 | 久久精品中文字幕第一页国产精品 | a毛片免费全部播放无风险 www.一级毛片 | 老头埋进校花里面使劲添 | 麻豆精品久久久一区二区 | 97亚洲熟妇自偷自拍另类图片 | GOGO人体大胆全球少妇 | 日本三级带日本三级带黄国产 | 国产欧美精品一区二区色综合 | 粉嫩大学生无套内射无码专区久久 | 国产超碰人人做人人爰 | 免费观看成人久久网免费观看 | 在线观看亚洲AV无码每日更新 | 精品无人区一区二区三区 | 337p日本欧洲亚洲大胆 | 久久久久久久无码中文字幕爆 | 欧美性猛交XXXX乱大交极品 | 天堂网www天堂在线中文 | 女人被狂躁C到高潮 | 全黄H全肉短篇禁乱NP慕浅浅 | 中文字幕AV在线一二三区 | 狂野欧美激情性XXXX在线观看 | 日韩精品福利视频一区二区三区 | 久色乳综合思思在线视频 | 99在线精品国自产拍中文字幕 |