亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
91久久精品无码一级毛片,A级毛片无码久久精品免费,成AV免费大片黄在线观看
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Mouse Anti-IDE/BF555 Conjugated antibody (bsm-33089M-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bsm-33089M-BF555
英文名稱 Mouse Anti-IDE/BF555 Conjugated antibody
中文名稱 BF555標記的胰島素降解酶單克隆抗體
別    名 BC2; Insulin degrading enzyme; FLJ35968; insulin protease; insulinase; insulysin; Abeta-degrading protease; FLJ35968; Ide; IDE_HUMAN; Insulin-degrading enzyme; OTTHUMP00000020097.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  細胞生物  免疫學  信號轉(zhuǎn)導  生長因子和激素  糖尿病  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 5H4
交叉反應 (predicted: Human, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 117kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IDE
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Insulysin was identified nearly a century ago as an enzyme responsible for the degradation of insulin in cells, although the precise interactions between insulin and insulysin remain elusive. Human insulysin was cloned in 1988, and shown to be a 118 kDa protein that exists primarily as a homodimer, and perhaps also complexed with other molecules. The sequence is well conserved between humans, rats and mice, and the antibody recognizes these species. Insulysin is a metalloproteinase of the clan ME, family M16, which contains an active site HxxEH, a reversal of the canonical HExxH zinc binding motif. Considered a zinc metalloproteinase, the activity of insulysin can be blocked with EDTA or 1-10 phenanthroline. In addition to the active metalloproteinase domain, insulysin contains a second metalloproteinase site which is considered catalytically inactive, and is thought to assist in substrate binding. Insulysin is most closely related to the bacterial proteinase pitrilysin, (the human orthologue of which appears to be MPRP1) and the mammalian proteinsae nardilysin. Generally thought to be a cytoplasmic protein, insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B chain, glucagon, denatured hemoglobin, alpha amyloid protein, TGF alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer’s disease research. The pH optimum for insulysin is basic, pH 8.5, which also distinguishes it from other metalloproteinases.
Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma secretase cleaved APP that may function in nuclear signaling.

Function:
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.

Subunit:
Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus.

Subcellular Location:
Cytoplasm. Cell surface. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.

Post-translational modifications:
The N-terminus is blocked.

Similarity:
Belongs to the peptidase M16 family.

Database links:

Entrez Gene: 3416 Human

Entrez Gene: 15925 Mouse

Entrez Gene: 25700 Rat

Omim: 146680 Human

SwissProt: P14735 Human

SwissProt: Q9JHR7 Mouse

SwissProt: P35559 Rat

Unigene: 500546 Human

Unigene: 28366 Mouse

Unigene: 45029 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
成人免费黄色大片 | 国产精品内射久久久久欢欢 | 无码AV免费精品一区二区三区 | 国内大量揄拍人妻在线视频 | 一级毛片免费播放 | 麻豆蜜桃国产精品无码视频 | 五十丰满熟妇性旺盛 | 亚洲中文字幕无码久久1 | 成人国产射精AV在线 | 亚洲国产天堂99精品一区 | 顶级欧美做受XXX000 | 蜜芽192.MON牢记永不失联 | 黄乱色伦短篇小说 | 一本久久a久久精品亚洲 | 欧美日韩国产综合视频在线观看 | 国产精品免费视频一区二区三区 | 麻豆国产精品无码AV在线 | 韩日午夜在线资源一区二区 | 国产三级在线免费 | 无码av高清毛片在线看 | 80年代十大欧美成人片 | 又粗又硬大战丰满少妇柔 | 欧美性爱视频在线播放 | 久久精品国产免费观看频道 | 精品国产乱码久久久久久呢 | 日本夜爽爽一区二区三区 | 欧美日韩精品久久久免费观看 | 一级毛片免费在线观看网站 | 日韩中文字幕无码R级电影 色婷婷AV一区二区三区在线观看 | 99在线精品国自产拍中文字幕 | 国产无遮挡又黄又爽在线视频 | 日本VS亚洲VS韩国一区三区四区 | 岳每晚被弄得嗷嗷叫高潮 | 老司机在线精品视频网站 | 九九精品免费观看在线 | 久久夜色国产亚洲色欲AV | 国产精品白浆无码流出.在线观看 | 国产成人一区二区啪在线观看 | 最美情侣高清免费观看在线 | AV无码久久久久不卡 | 极品人妻少妇一区二区三区 |