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Rabbit Anti-NCR1/PE-Cy5.5 Conjugated antibody (bs-23550R-PE-Cy5.5)
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-23550R-PE-Cy5.5
英文名稱 Rabbit Anti-NCR1/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的細(xì)胞毒性受體NK-p46抗體
別    名 Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335; CD 335; LY94; NCTR1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NCR1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.

Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Subunit:
Interacts with CD247 and FCER1G.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Selectively expressed by both resting and activated NK cells.

Similarity:
Belongs to the natural cytotoxicity receptor (NCR) family.
Contains 2 Ig-like (immunoglobulin-like) domains.

Database links:

Entrez Gene: 9437 Human

Entrez Gene: 17086 Mouse

Entrez Gene: 117547 Rat

Omim: 604530 Human

SwissProt: O76036 Human

SwissProt: Q8C567 Mouse

SwissProt: Q9Z0H5 Rat

Unigene: 97084 Human

Unigene: 240231 Mouse

Unigene: 30049 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NKp46是很重要的的自然細(xì)胞毒受體,在自然殺傷作用中起關(guān)鍵作用。細(xì)胞毒性受體家族(NCRs)主要有:NKp46、NKp44和NKp30,其中NKp46和NKp30表達(dá)于所有靜止和活化的NK細(xì)胞,而NKp44則選擇性的表達(dá)于活化的NK細(xì)胞。靶細(xì)胞上的配體分子與NCRs的結(jié)合(交聯(lián))引發(fā)NK細(xì)胞的活化導(dǎo)致靶細(xì)胞的裂解和大量細(xì)胞因子的產(chǎn)生?,F(xiàn)已確認(rèn)NKp46和NKp44可以識(shí)別病毒上的配體分子紅血球凝聚素,而NKp46則能識(shí)別腫瘤細(xì)胞上的乙酰硫酸多聚糖。
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