亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
日韩精品欧美视频,一级a一级a爰片免费免免2021,91成人啪国产啪永久地址
Rabbit Anti-Fibulin 5/PE-Cy3 Conjugated antibody (bs-23735R-PE-Cy3)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-23735R-PE-Cy3
英文名稱(chēng) Rabbit Anti-Fibulin 5/PE-Cy3 Conjugated antibody
中文名稱(chēng) PE-Cy3標(biāo)記的衰老關(guān)鍵蛋白抗體
別    名 ARMD3; Dance; Developmental arteries and neural crest EGF like protein; FBLN5; FIBL 5; Developmental arteries and neural crest EGF-like protein; EVEC; Fbln5; FBLN5_HUMAN; UP50; FIBL 5; FIBL-5; Fibulin-5; FLJ90059; Urine p50 protein.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  內(nèi)分泌病  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Fibulin 5
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Fibulin 5: A protein that belongs to a family of extracellular proteins expressed in the basement membranes of blood vessels. Fibulin 5 may be essential for the polymerization of elastin. Missense mutations in FBLN5, the gene that encodes fibulin 5, appear responsible for 1-2% of cases of age-related macular degeneration (AMD). FBLN5 is located on chromosome 14 in band 14q32.1. See also: Fibulin 3. May play a role in vascular growth and maturation during development and in lesions of injured vessels.

Function:
Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.

Subunit:
Homodimer.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes.

DISEASE:
Cutis laxa, autosomal dominant, 2 (ADCL2) [MIM:614434]: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Note=The disease is caused by mutations affecting the gene represented in this entry.
Cutis laxa, autosomal recessive, 1A (ARCL1A) [MIM:219100]: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. Type I autosomal recessive cutis laxa is a specific, life-threatening disorder with organ involvement, lung atelectasis and emphysema, diverticula of the gastrointestinal and genitourinary systems, and vascular anomalies. Associated cranial anomalies, late closure of the fontanel, joint laxity, hip dislocation, and inguinal hernia have been observed but are uncommon. Note=The disease is caused by mutations affecting the gene represented in this entry.
Age-related macular degeneration 3 (ARMD3) [MIM:608895]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity:
Belongs to the fibulin family.
Contains 6 EGF-like domains.

Database links:

Entrez Gene: 10516 Human

Entrez Gene: 23876 Mouse

Omim: 604580 Human

SwissProt: Q9UBX5 Human

SwissProt: Q9WVH9 Mouse

Unigene: 332708 Human

Unigene: 288381 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Fibulin-5 Fibulin-5亦稱(chēng)為FBLN-5、DANCE或EVEC是細(xì)胞外基質(zhì)蛋白質(zhì)家族的一員,在組織器官發(fā)育、重塑和修復(fù)過(guò)程中起重要作用,并與內(nèi)皮細(xì)胞相互作用.Fibulin-5廣泛分布于富含彈性蛋白的組織, 能直接與原彈性蛋白結(jié)合,并將后者錨于細(xì)胞表面,這對(duì)形成彈性纖維十分關(guān)鍵, 對(duì)血管的發(fā)育和修復(fù)具有重要作用.此外,Fibuljn-5還能促進(jìn)創(chuàng)口愈合, 與細(xì)胞的增殖、運(yùn)動(dòng)和侵襲有關(guān)
fibulin-5有學(xué)者稱(chēng)“皮膚衰老關(guān)鍵蛋白”與皮膚彈性有關(guān)的蛋白,對(duì)于起著固定細(xì)胞外壁、保持肌膚緊繃、維護(hù)肺部和血管柔韌性作用的彈性纖維的發(fā)育十分關(guān)鍵.
還有學(xué)者認(rèn)為:fibulin-5能夠抑制血管的形成,該蛋白質(zhì)在腫瘤轉(zhuǎn)移過(guò)程中表達(dá)降低或消失,將有可能用于腫瘤治療方面的研究。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产呦精品一区二区三区下载 | 成人夜剧电影在线播放 | 精品无人乱码高清在线观看 | 亚洲高清在线精品一区 | 天天做天天爱天天爽综合网 | 国产精品成人99久久久久 | 免费一级毛片在线观看 | 国产精品一区二区AV日韩在线 | 奇米狠狠一区二区三区 | 777久久精品一区二区三区无码 | 538在线视频一区二区视视频 | 天堂中文最新版在线官网在线 | 国产一区二区三区影院 | 久久国产精品偷任你爽任你A | 色综合精品无码一区二区三区 | 免费看人与动人物XXXX | 精品国产乱码久久久久久浪潮 | 亚洲欧美在线观看H片 | 亚洲AV无码乱码国产麻豆穿越 | 亚洲精品毛片永久播放 | 色青青草原桃花久久综合 | 国产精品高潮视亚洲乱码 | 精品一区二区三区高清免费观看 | 午夜福利电影网站鲁片大全 | 无码纯肉国产麻豆久久 | 免费 无码 国产真人视频九色 | 国产系列视频二区 | 久久免费精品高清麻豆 | 国产99久久亚洲综合精品 | 精品人妻无码一区二区三区在线 | mdapptv麻豆下载 | 日本DVD专区中文在线 | 欧美精品一本久久男人的天堂 | 免费欧美黄色网址 | 一级毛片丰满**出奶水 | 日韩无码高清福利在线看 | 中文字幕日韩精品有码视频 | 久久久久久曰本av免费免费 | 午夜熟女插插XX免费视频 | 最近中文字幕mv免费高清在线视频 | 韩国免费一级a一片在线播放 |