亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
九九精品免费观看在线,18禁黄网站禁片免费观看久久
Rabbit Anti-Fibulin 5/BF555 Conjugated antibody (bs-23735R-BF555)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-23735R-BF555
英文名稱 Rabbit Anti-Fibulin 5/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的衰老關(guān)鍵蛋白抗體
別    名 ARMD3; Dance; Developmental arteries and neural crest EGF like protein; FBLN5; FIBL 5; Developmental arteries and neural crest EGF-like protein; EVEC; Fbln5; FBLN5_HUMAN; UP50; FIBL 5; FIBL-5; Fibulin-5; FLJ90059; Urine p50 protein.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  內(nèi)分泌病  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Fibulin 5
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Fibulin 5: A protein that belongs to a family of extracellular proteins expressed in the basement membranes of blood vessels. Fibulin 5 may be essential for the polymerization of elastin. Missense mutations in FBLN5, the gene that encodes fibulin 5, appear responsible for 1-2% of cases of age-related macular degeneration (AMD). FBLN5 is located on chromosome 14 in band 14q32.1. See also: Fibulin 3. May play a role in vascular growth and maturation during development and in lesions of injured vessels.

Function:
Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.

Subunit:
Homodimer.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes.

DISEASE:
Cutis laxa, autosomal dominant, 2 (ADCL2) [MIM:614434]: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Note=The disease is caused by mutations affecting the gene represented in this entry.
Cutis laxa, autosomal recessive, 1A (ARCL1A) [MIM:219100]: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. Type I autosomal recessive cutis laxa is a specific, life-threatening disorder with organ involvement, lung atelectasis and emphysema, diverticula of the gastrointestinal and genitourinary systems, and vascular anomalies. Associated cranial anomalies, late closure of the fontanel, joint laxity, hip dislocation, and inguinal hernia have been observed but are uncommon. Note=The disease is caused by mutations affecting the gene represented in this entry.
Age-related macular degeneration 3 (ARMD3) [MIM:608895]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity:
Belongs to the fibulin family.
Contains 6 EGF-like domains.

Database links:

Entrez Gene: 10516 Human

Entrez Gene: 23876 Mouse

Omim: 604580 Human

SwissProt: Q9UBX5 Human

SwissProt: Q9WVH9 Mouse

Unigene: 332708 Human

Unigene: 288381 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Fibulin-5 Fibulin-5亦稱為FBLN-5、DANCE或EVEC是細(xì)胞外基質(zhì)蛋白質(zhì)家族的一員,在組織器官發(fā)育、重塑和修復(fù)過(guò)程中起重要作用,并與內(nèi)皮細(xì)胞相互作用.Fibulin-5廣泛分布于富含彈性蛋白的組織, 能直接與原彈性蛋白結(jié)合,并將后者錨于細(xì)胞表面,這對(duì)形成彈性纖維十分關(guān)鍵, 對(duì)血管的發(fā)育和修復(fù)具有重要作用.此外,Fibuljn-5還能促進(jìn)創(chuàng)口愈合, 與細(xì)胞的增殖、運(yùn)動(dòng)和侵襲有關(guān)
fibulin-5有學(xué)者稱“皮膚衰老關(guān)鍵蛋白”與皮膚彈性有關(guān)的蛋白,對(duì)于起著固定細(xì)胞外壁、保持肌膚緊繃、維護(hù)肺部和血管柔韌性作用的彈性纖維的發(fā)育十分關(guān)鍵.
還有學(xué)者認(rèn)為:fibulin-5能夠抑制血管的形成,該蛋白質(zhì)在腫瘤轉(zhuǎn)移過(guò)程中表達(dá)降低或消失,將有可能用于腫瘤治療方面的研究。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
内射国产老熟女综合导航 | 国产一级毛片在线 | …久久精品99久久香蕉国产 | 在线看片免费人成视频电影sM | 国产成人精品免费视频大全 | 国产成人一区二区啪在线观看 | 欧美精品一本久久男人的天堂 | 米奇奇米777第四色 国产精品免费大片 | A级黄韩国在线观看免费 | 亚洲国产第一区二区三区 | 在线观看特色大片免费视频 | 中国特级黄一级**毛片 | 国产女人18毛片水真多 | 五月天婷五月天综合网 | 麻豆精产国品免费免费观看高清 | 国产美女视频一区二区二三区 | 猛烈的抽插她丰满白嫩 | 真人一级一级毛片免费观看 | 久久精品这里热有精品6 | 精品国产福利一区二区在线 | 无码人妻AⅤ一区二区三区夏目 | 成人免费无码精品国产电影WWW | 91精品国产91久久综合 | 羞羞漫画官方页面弹窗 | 为您提供久久久久精品免费看 | 久久亚洲AV无码精品福利 | 99国产亚洲精品无码成人69V | 极品尤物喷水爆白浆呻吟小说 | 精品99久久一A毛免费观看 | 男男体育生乱yin高H肉汁 | 成全视频观看免费高清动漫 | 亚洲欧美日韩一区二区在线观看 | 无套内射在线观看THEPORN | 国产做a爱一级毛片久久 | 麻豆人妻少妇精品无码区 | 欧美人与动牲交ZOOZ乌克兰 | 无码视频在线肉在线播放美熟女 | 麻豆国产精品无码AV在线 | 99久久免费精品高清特色大片 | 久久久久久久国产免费看 | 国产黄A真人一级无码毛片一区二区三区 |