亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
伊人狠狠丁香婷婷综合尤物,亚洲一区免费观看,免费一级肉体全黄毛片365看片
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Mouse Anti-HLA-DR-FITC/PE-Cy7 Conjugated antibody (bsm-30090M-FITC-PE-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bsm-30090M-FITC-PE-Cy7
英文名稱 Mouse Anti-HLA-DR-FITC/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標記的FITC標記小鼠抗HLA-DR單克隆抗體
別    名 DR alpha chain precursor; DRB1; DRB4; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen DR alpha chain; HLA DR1B; HLA DR3B; HLA DRA; HLA DRA1; HLA DRB1; HLA DRB3; HLA DRB4; HLA DRB5; HLADR4B; HLADRA1; HLADRB; Major histocompatibility complex class II DR alpha; Major histocompatibility complex class II DR beta 1; Major histocompatibility complex class II DR beta 3; Major histocompatibility complex class II DR beta 4; Major histocompatibility complex class II DR beta 5; MGC117330; MHC cell surface glycoprotein; MHC class II antigen DRA; MHC II; DRA_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  免疫學  
抗體來源 Mouse
克隆類型 Monoclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性    狀 Liquid
濃    度 1mg/ml
免 疫 原
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq]

Function:
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments.

Subunit:
Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms an heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain).

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Post-translational modifications:
Ubiquitinated by MARCH1 or MARCH8 at Lys-244 leading to down-regulation of MHC class II. When associated with ubiquitination of the beta subunit of HLA-DR: HLA-DRB4 'Lys-254', the down-regulation of MHC class II may be highly effective.

Similarity:
Belongs to the MHC class II family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 3122 Human

Omim: 142860 Human

SwissProt: P01903 Human

Unigene: 520048 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
小骚妇下面水多要插视频 | 女人被男人吃奶到高潮 | 亚洲精品国产日韩无码AV永久免费网 | 被伴郎的内捧猛烈进出H视频 | 久久91亚洲精品中文字幕 | 亚洲.国产.一区二区三区 | 欧美高清视频www夜色资源网 | 亚洲欧美日本韩国 | 久青草国产97香蕉在线视频 | 在线观看欧美人与动物性交 | 欧美日韩在线精品一区二区三区激情综合 | 欧美肥胖老太vidio在线视频 | 欧美va欧美va在线 | 国产精品免费露脸视频 | 国产成a人亚洲精v品久久网 | 三级毛片在线播放 | 日本动态120秒免费 小宝极品内射国产在线 | 丰满少妇被猛烈进入无码蜜桃 | 亚洲欧美一区二区成人片 | 日本人妻JAPANESEXXXXHD | 高潮毛片无遮挡免费高清 | 特级毛片内射WWW无码 | 国产一区二区无码中文 | 午夜dv内射一区二区 | 好好的曰com久久 | 中文在线а√天堂官网 | jizz国产精品网站 | 国产区免费在线观看 | 一区二区三区日韩免费播放 | 午夜福利理论片中文字幕 | 一本久道综合在线无码人妻 | 欧美日韩精品一区二区三区高清视频 | 内地级A艳片高清免费播放 国产精品无码不卡系列在线 | 精品粉嫩国产48尤物在线播放 | 精品一区二区三区免费观看 | 免费在线观看的毛片 | 亚瑟TV私人网站 | 亚洲最大视频网站 | 国产91无毒不卡在线观看 | 成全视频免费高清观看在线 | 俺去俺来也在线www色官网 |