亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美性狂猛bbbbbbxxxx,黄色网页免费观看
Mouse Anti-human CD45-FITC/BF350 Conjugated antibody (bsm-30083M-FITC-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bsm-30083M-FITC-BF350
英文名稱 Mouse Anti-human CD45-FITC/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的FITC標(biāo)記小鼠抗人CD45單克隆抗體
別    名 B220; CD 45; CD-45; cd45 antigen; ec3.1.3.48; CD45R; GP180; GP180; GP 180; L CA; LCA; L-CA; Leukocyte common antigen; LY5; Ly-5 glycoprotein; Protein tyrosine phosphatase receptor type C; Protein tyrosine phosphatase receptor type c polypeptide; protein tyrosine phosphatase, receptor type, C; Receptor-type tyrosine-protein phosphatase C; PTPRC; PTPRC_HUMAN; SCID due to PTPRC deficiency; T200; T200 glycoprotein; T200 leukocyte common antigen; Human homolog of severe combined immunodeficiency due to PTPRC deficiency.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  干細胞  細胞表面分子  糖蛋白  細胞類型標(biāo)志物  自然殺傷細胞  淋巴細胞  t-淋巴細胞  b-淋巴細胞  
抗體來源 Mouse
克隆類型 Monoclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 143kDa
性    狀 Liquid
濃    度 1mg/ml
免 疫 原
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008].

Function:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.

Subunit:
Binds GANAB and PRKCSH. Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Contains 2 tyrosine-protein phosphatase domains.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.

Post-translational modifications:
Heavily N- and O-glycosylated.

DISEASE:
Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 tyrosine-protein phosphatase domains.

Database links:

Entrez Gene: 5788 Human

Omim: 151460 Human

SwissProt: P08575 Human

Unigene: 654514 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产小视频在线高清播放 | 18禁无码国内精品久久综合88 | 动漫人物自慰喷水网站 | 亚日韩一二三区视频免费看 | 一本久久a久久精品免费不卡 | 国产三级日产三级国产AV多人 | 最近免费中文字幕大全高清MV | 九九久久精品国产免费看小说 | 中文无码熟妇人妻AV在线 | 亚洲中文字幕无码中文字无摸 | 玩白嫩少妇小泬高潮18P | 国产精品自在线拍国产不卡 | 丁香六月久久婷婷开心 | 日本韩国亚洲综合日韩欧美国产 | 久久久久亚洲AV手机播放 | 国产一级精品免费看高清99 | 亚洲美女又黄又爽在线观看 | 免费麻豆国产黄网站在线观看 | 亚洲成AV人片在线观看WV | 国产福利在线免费 | 中文字幕人妻无码系列第三区 | 一个人看的免费视频大全在线观看 | 日日摸日日踫夜夜爽无码 | 午夜dv内射一区二区 | 日韩欧美高清黄大片色成人精品香蕉在线看 | 亚洲欧洲日本无在线码天堂 | 欧美精品一卡二卡 | 欧美特级午夜一区二区三区 | 深夜久久AAAAA级毛片免费看 | 日本午夜免费啪视频在线 | 国产精品亚洲lv粉色 | 日本中文字幕乱码免费 | 国产欧美精品123区发布 | 亚洲二区在线视频 | 456亚洲人成影院在线观 | 久久久这里只有精品免费 | 日本乱子人伦在线视频 | 中文字幕日韩专区下载 | 91精品国产麻豆国产自产在线 | 国产欧美日韩综合精品一区二区 | 精品国产专区91在线 |