亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線(xiàn):400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
久久久精品国产亚洲AV无码,久久综合经典国产二区无码
Rabbit Anti-IRS-4/FITC Conjugated antibody (bs-23362R-FITC)
訂購(gòu)熱線(xiàn):400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-23362R-FITC
英文名稱(chēng) Rabbit Anti-IRS-4/FITC Conjugated antibody
中文名稱(chēng) FITC標(biāo)記的胰島素受體底物-4抗體
別    名 IRS4; 160 kDa phosphotyrosine protein; Insulin receptor substrate 4; IRS 4; PY160; IRS4_HUMAN; IRS-4; Phosphoprotein of 160 kDa; pp160.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 心血管  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  糖尿病  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 134kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IRS-4
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
IRS4 (Insulin receptor substrate 4) is a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signaling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.

Function:
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.

Subunit:
Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH. Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1. Interacts with PIK3R1 and GRB2.

Subcellular Location:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Expressed in skeletal muscle, brain, heart, kidney and liver.

Post-translational modifications:
Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-894 in response to FGF2 signaling. Phosphorylation of Tyr-894 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction.

Similarity:
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 8471 Human

 Entrez Gene: 16370 Mouse

Entrez Gene: 315350 Rat

Omim: 603510 Human

SwissProt: O14654 Human

SwissProt: Q9Z0Y7 Mouse

Unigene: 460872 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
欧美R级荡公乱妇在线观看 免费看的一级毛片 | 欧美一级二级三级 | 国产亚洲成AⅤ人片在线观看 | 猛烈的抽插她丰满白嫩 | 欧美精品视频免费观看 | 免费看撕开奶罩揉吮奶头视频 | 被两个两个黑人吃奶4P | 精品欧美一区二区三区久久久 | 成人毛片100免费观看 | 少妇被躁爽到高潮无码人狍大战 | 菠萝菠萝蜜影视在线观看小草免费 | 亚洲欧美一区二区三区四区 | 人妻精品久久久久中文字幕69 | 日韩精品欧美在线视频在线 | 又大又粗又爽的少妇免费视频 | 精品国产免费观看久久久 | 亚洲精品自产拍在线观看 | 午夜dv内射一区二区 | 国产精品老熟女视频一区二区 | 久久综合色一综合色88 | 嫩交18xxxx| 久久久无码精品一区二区三区 | 人妻无码专区一专区二专区三 | 午夜国产精品免费观看 | 亚洲乱码精品久久久久.. | 伊人久久大香线蕉成人综合网 | 欧美最猛激情性AAAAA | 亚洲综合AV在线在线播放 | 国产人成高清在线视频99 | 性饥渴艳妇K8经典色欲 | 国产娱乐凹凸视觉盛宴在线视频 | 狂躁美女大BBBBBB视频1 | 最近中文字幕在线看免费完整版 | 亚洲91无码精品一区在线播放 | 国产AAAAA一级毛片无下载 | 91精品国产人成网站 | 丝袜情趣在线资源二区 | 91系列在线观看免费 | 国产免费久久久久久久无码浪潮 | 欧美乱码精品一区二区三区卡 | 91精品国产高清一区二区三蜜臀 |