亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
无码一级a一片免费看,日韩欧美一区二区三区在线
Rabbit Anti-IRS-4/BF594 Conjugated antibody (bs-23362R-BF594)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-23362R-BF594
英文名稱 Rabbit Anti-IRS-4/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的胰島素受體底物-4抗體
別    名 IRS4; 160 kDa phosphotyrosine protein; Insulin receptor substrate 4; IRS 4; PY160; IRS4_HUMAN; IRS-4; Phosphoprotein of 160 kDa; pp160.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 心血管  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  糖尿病  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 134kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IRS-4
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
IRS4 (Insulin receptor substrate 4) is a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signaling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.

Function:
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.

Subunit:
Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH. Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1. Interacts with PIK3R1 and GRB2.

Subcellular Location:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Expressed in skeletal muscle, brain, heart, kidney and liver.

Post-translational modifications:
Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-894 in response to FGF2 signaling. Phosphorylation of Tyr-894 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction.

Similarity:
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 8471 Human

 Entrez Gene: 16370 Mouse

Entrez Gene: 315350 Rat

Omim: 603510 Human

SwissProt: O14654 Human

SwissProt: Q9Z0Y7 Mouse

Unigene: 460872 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国禁国产you女视频网站 | 久久se精品一区二区国产 | 综合久久狠狠色99h中午 | 欧美精品一区二区三区中 | 欧美日韩国产综合视频一区二区 | 久久久久亚洲视频 | 亚洲AV无码专区在线观看 | 国产啪精品视频网免费 | 特黄四级人牲片在线观看 | 性一交一乱一色一免费无遮挡 | 香港三级精品三级在线专区 | 欧美成人另类精品乱码免费不卡播放 | 国产又粗又大又爽又免费视频 | 特级做a爰片毛片免费69 | 人人妻人人澡人人爽av | 全黄裸片一29分钟免费真人版 | 欧美精品一区二区在线观看播放 | 漂亮人妻被中出中文字幕色 | 最近最新的中文字幕国语在线 | 欧美日韩一区二区三区自拍 | 无限资源免费观看视频大全 | 日欧精品卡2卡3卡4卡5卡L | 两根大肉大捧一进一出好爽视频 | 曰韩欧美群交P片内射 | 日韩三级中文字幕 | 欧美激情成a人在线观看 | 国产精品亚洲第一区在线 | 日韩免费视频在线观看免费 | 小货SAO边洗澡边CAO你动漫 | 一级av一片久久免费观看 | 亚洲国产精品剧情污污 | 国产精品自产拍在线观看中文 | 欧美激情一区二区三区蜜桃视频 | 午夜精品成人一区二区视频 | 国产又爽又黄无码无遮挡在线观点 | 91资源在线播放 | 麻豆国产精品无码AV在线 | 免费国产美女爽到喷出水来视频 | 亚洲国产精品人人爽夜夜爽 | 欧美午夜性春猛交XXXX | 天天躁夜夜躁狠狠是什么心态 |