亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
最新av中文字幕无码专区,人人妻人人澡人人爽国产一区,男女激情无遮挡免费视频
Mouse Anti-MMP14/BF350 Conjugated antibody (bsm-51028M-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bsm-51028M-BF350
英文名稱 Mouse Anti-MMP14/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的小鼠抗基質(zhì)金屬蛋白酶-14單克隆抗體
別    名 MMP 14; MMP-14; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP; MMP-X1; MT-MMP; MMP14_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 3A6
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMP14
亞    型 IgM
純化方法 affinity purified by Protein AGL
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane-type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.
MMP14 may be an activator of pro gelatinase A and is expressed in fibroblast cells during both wound healing and human cancer progression. MMP14 is expressed in very low levels and may require stimulation with concanavolin A or the phorbol ester TPA to stimulate production of MMP14.
Matrix metalloproteinase-14 precursor is endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. [Catalytic activity] Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain. Highly expressed in placenta, kidney, heart, lung, embryonic skeletal and periskeletal tissues. Belongs to the peptidase M10A family.

Function:
Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7.

Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Tissue Specificity:
Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.

Post-translational modifications:
The precursor is cleaved by a furin endopeptidase.

Similarity:
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.

Database links:

Entrez Gene: 4323 Human

Entrez Gene: 17387 Mouse

Entrez Gene: 81707 Rat

Omim: 600754 Human

SwissProt: P50281 Human

SwissProt: P53690 Mouse

SwissProt: Q10739 Rat

Unigene: 2399 Human

Unigene: 280175 Mouse

Unigene: 10371 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
一级做a爰片久久毛片毛片 色哟哟国产精品一区二区真心好看 | 澳门永久av免费网站 | 久久国产亚洲电影天堂 | 囯产精品一品二区三区 | 色欲精品人妻AV一区二区三区 | 四虎国产精品永久地址入口 | 一级A爱做片免费观看国产 成人MV射精无打码视频 | 韩剧《空洞》在线观看 | 亚洲熟妇一区二区三区 | 开心婷婷五月综合基地 | 熟女作爱一区二区视频 | 久久精品国产9久久综合 | 成人国产精品一级毛片视频 | 97se亚洲综合自在线尤物 | 中文字幕亚洲精品乱码APP | 337p日本欧洲亚洲大胆 | 日韩精品区一区二区三VR | 水蜜桃亚洲一二三四在线 | 囯精产品一品二品国精91 | 久久久国产精品综合无人区 | 狠狠做深爱婷婷久久综合一区 | 图片区乱熟图片区小说 | 国产黄A真人一级无码毛片一区二区三区 | 三根一起进出h黄蓉太疼了 国产在线观看www鲁啊鲁免费 | 宝贝乖调教跪趴SM主人玩具HH | 狠狠色丁香婷婷久久综合 | 精品福利一区二区三区免费视频 | 亚洲人人夜夜澡人人爽 | 免费无毒A网站在线观看 | 国产女高清在线看免费观看 | 亚洲国产成人精品刺激内射白浆 | 国产亚洲午夜精品a一区二区 | 国产真实女人一级毛片 | 国产人人怕人人干视频 | 日本老妇一级特黄aa大片 | 18视频入口网站在线看 | 一级特黄特色的免费大片视频 | 中文字幕大香视频蕉无码... | 色婷婷国产精品无码视频 | 人妻互换免费中文字幕网站 | yellow片免费观看在线 |